نتایج جستجو برای: il 1ß
تعداد نتایج: 139923 فیلتر نتایج به سال:
The present study deals with the isolation of fourteen compounds from the active ethyl acetate (MPE) extract of M. pudica (L.) whole plant and their subsequent evaluation for the nitric oxide (NO), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1ß) inhibitory activities in lipopolysaccharide (LPS) stimulated RAW 264.7 and J774A.1 cells. Among the tested compounds, L-mimosine (12...
The existence of the ocular microbiota has been reported but functional analyses to evaluate its significance in regulating ocular immunity are currently lacking. We compared the relative contribution of eye and gut commensals in regulating the ocular susceptibility to Pseudomonas aeruginosa-induced keratitis. We find that in health, the presence of microbiota strengthened the ocular innate imm...
Introduction Monosodium urate (MSU) crystal induced interleukin-1 (IL-1b) secretion is a critical pathogenic factor in the development of gout and serves as therapeutic target in these patients. Nevertheless, without co-stimulation by a pro-IL-1ß inducing factor, e.g. lipopolysaccharides (LPS), MSU alone cannot induce IL-1b secretion in vitro. The endogenous Toll-like receptor 4 (TLR-4) agonist...
background: new discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. we aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. based on the general faster progression rate of wrist osteoarthritis, we hypothes...
Introduction: Controversy remains over mechanisms by which nutriceuticals may lead to modulation of disease symptoms and cartilage degradation in osteoarthritis (OA), and which product is preferred for treatment of OA. Therefore, the purpose of this study was to evaluate the effects of glucosamine and chondroitin sulfate on chondrocyte viability, extracellular matrix production, markers of infl...
Dry eye syndrome (DES) is a common eye disease. Artificial tears (AT) are used to treat DES, but they are not effective. In this study, we assessed the anti-inflammatory effect of AT containing epigallocatechin gallate (EGCG) and hyaluronic acid (HA) on DES. Human corneal epithelial cells (HCECs) were used in the WST-8 assay to determine the safe dose of EGCG. Lipopolysaccharide-stimulated HCEC...
INTRODUCTION Osteoarthritis (OA) is characterized by an imbalance in cartilage and underlying subchondral bone homeostasis. We hypothesized that signals from the subchondral bone may modulate production of matrix components, alter chondrogenic differentiation potential of cocultured bone marrow-derived mesenchymal stem cells (BMSC) and induce a phenotypic shift in differentiated OA chondrocytes...
often involved in tumorigenesis. Recent exhaustive cDNA microarray analyses in human neoplasms expanded knowledge of such molecules. Hepatocyte nuclear factor-1ß (HNF-1ß) is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF-1α. In contrast to HNF-1α, HNF-1ß is very weakly expressed in the liver and is commonly expressed in the kidneys. During human embryonic ...
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