نتایج جستجو برای: il 13
تعداد نتایج: 462785 فیلتر نتایج به سال:
Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)alpha and IL-13Ralpha1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Ralpha2, whose function in IL-13 signaling is unknown. To better...
the link between il-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. at the present study, we address the role of b cell derived il-13 in the ige and other immunoglobulin development. antisense oligo for human il-13 m-rna was used to study ige down regulation. human b-lymphocytes were purified by positive selecti...
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and well validated therapeutic target for the treatment of asthma, along with other allergic inflammatory diseases. IL-13 signals through ternary signalling complex formed receptors IL-13Rα1 IL-4Rα. This assembled by initially binding IL-13Rα1, followed association binary IL-13:IL-13Rα1 The are shared IL-4, but IL-4 binds ...
Although previous literature suggests that interleukin (IL)-13, a T-helper type 2 cell effector cytokine, might be involved in the pathogenesis of pulmonary hypertension (PH), direct proof is lacking. Furthermore, a potential mechanism underlying IL-13-induced PH has never been explored. This study's goal was to investigate the role and mechanism of IL-13 in the pathogenesis of PH. Lung-specifi...
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