background: single nucleotide polymorphism in the interleukin28b (il28b) gene was recently shown to be associated with a significant increase in response to interferon-α and ribavirin treatment in patients with chronic hepatitis c. similarly, thyroid disease (td) occurring during treatment confer an improved sustained virologic response (svr). objectives: to determine the role of il28b genotype...

cataract is multi-factorial eye disease identified by the disturbance of the transparent ocular lens. there is significant evidence suggesting oxidative damage as a major cause of initiation and progression of numerous diseases including cataracts. nad(p)h:quinone oxidoreductase 1 (nqo1; omim: 125860) and catalase (cat, omim: 115500) are antioxidant enzymes that prevent cells from oxidative str...

Abstract The exposure to linezolid is characterized by a large inter-individual variability; age, renal dysfunction and body weight explain this variability only limited extent considerable portion of it remains unexplained; therefore, we decided investigate the role individual genetic background focusing in particular on risk underexposure. 191 patients therapy with at standard dose 600 mg twi...

objective: low density lipo-protein receptor- related protein (lrp) is the most important cholesterol receptor in neurons. it serves as a receptor for apoe protein which is the most important risk factor for alzheimer’s disease. lrp also contributes to the ligation of lipoproteins with apoe in neurons. association between lrp c766t and alzheimer’s disease in iranian patients with late onset alz...

in this study, genetic diversity of 20 wheat genotypes was evaluated using 126 simple sequence repeats (ssr) alleles, covering all three wheat genomes. a total of 1557 allelic variants were detected for 126 ssr loci. the number of alleles per locus ranged from 4 to 19 and the allelic polymorphism information content (pic) varied from 0.66 (xgwm429) to 0.94 (xgwm212 and xgwm515). the high­est po...

results the results showed that there was no statistical significant difference in distribution of genotype (aa, ac and cc) and allele (a and c) frequencies between ms patients and healthy controls (p = 0.901 and p = 0.728, respectively). conclusions in conclusion, it appears that the c424c/a polymorphism within the il-25 gene has no significant relationship with ms, and this polymorphism is pr...

background: brucella is a gram-negative bacterium, causing acute and chronic infection in humans and animals. cell-mediated immunity is the main protective immune response against brucella spp. activation of macrophages by ifn-γ and generation of reactive oxygen intermediates and nitric oxide are the main immunologic mechanisms responsible for control of brucella infection. objective: to invest...

The present study carried out to with a view characterize and validate the RAPD marker’s genetic diversity at morphological molecular levels in thirty cultivars of onion (Allium cepa L.). This work aimed determine their important traits, DNA polymorphism decipher variation. agro-morphological characters such as germination percentage, plant height, leaf colour, waxiness, foliage attitude, bulk ...

OBJECTIVES Suppressor of cytokine signaling 3, myxovirus resistance protein and osteopontin gene polymorphisms may influence the therapeutic response in patients with chronic hepatitis C, and an association with IL28 might increase the power to predict sustained virologic response. Our aims were to evaluate the association between myxovirus resistance protein, osteopontin and suppressor of cyto...