نتایج جستجو برای: il7r
تعداد نتایج: 206 فیلتر نتایج به سال:
Citation: Vicente C, Schwab C, Broux M, Geerdens E, Degryse S, Demeyer S, Lahortiga I, Elliott A, Chilton L, La Starza R, Mecucci C, Vandenberghe P, Goulden N, Vora A, Moorman AV, Soulier J, Harrison CJ, Clappier E, and Cools J. Targeted sequencing identifies association between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia. Haematologica. 2015; 100:xxx doi...
Abstract INTRODUCTION The incidence of radiation necrosis (RN), a common and morbid side effect radiosurgical management brain metastases, is growing as patient survival use immunotherapy increases. RN thought to be immunologically driven; however, its pathophysiology remains poorly understood. Further, difficulty distinguishing it radiographically from recurrent metastatic disease often necess...
A mutation in the IL7Rα locus has been identified as a risk factor for multiple sclerosis (MS), a neurodegenerative autoimmune disease characterized by inflammation, demyelination, and axonal damage. IL7Rα has well documented roles in lymphocyte development and homeostasis, but its involvement in disease is largely understudied. In this study, we use the experimental autoimmune encephalomyeliti...
NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.
The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1-binding sites are insensitive to gamma-secretase inhibitors. Here, we demonstrate that fewer than 10% of NOTCH1-binding sites show dynamic changes...
Large case-control genome-wide association studies primarily expose common variants contributing to disease pathogenesis with modest effects. Thus, alternative strategies are needed to tackle rare, possibly more penetrant alleles. One strategy is to use special populations with a founder effect and isolation, resulting in allelic enrichment. For multiple sclerosis such a unique setting is repor...
مالتیپل اسکلروزیس(ms) یک بیماری خودایمن دمیلینه شدن سیستم عصبی مرکزی است و جزء بیماری های پیچیده در نظر گرفته می شود. چندین ژن در استعداد به بیماری دخیل هستند که بطور عمده شامل ژن های مربوط به سیستم ایمنی می باشند. از جمله این ژن ها، ژن زنجیره آلفای گیرنده اینترلوکین 7 (il7r) است که در همئوستاز و طول عمر لمفوسیت های t نقش دارد. rs6897932 یکی از پلی مورفیسم های تک نوکلئوتیدی (snp) شناخته شده در ...
Investigating Alternative Splicing and Polyadenylation of the Interleukin 7 Receptor (IL7R) exon 6: Implications for Multiple Sclerosis by Irina Evsyukova Department of Biochemistry Duke University Date:_______________________ Approved: ___________________________ Mariano A. Garcia-Blanco, Co-Supervisor ___________________________ Michael D. Been, Co-Supervisor ___________________________ G. Va...
Notch1 activation is essential for T-lineage specification of lymphomyeloid progenitors seeding the thymus. Progression along the T cell lineage further requires cooperative signaling provided by the interleukin 7 receptor (IL-7R), but the molecular mechanisms responsible for the dynamic and lineage-specific regulation of IL-7R during thymopoiesis are unknown. We show that active Notch1 binds t...
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