To perform high-throughput studies on the biological effects of ionizing radiation in vivo, we have implemented a microfluidic tool for microbeam irradiation of Caenorhabditis elegans. The device allows the immobilization of worms with minimal stress for a rapid and controlled microbeam irradiation of multiple samples in parallel. Adapted from an established design, our microfluidic clamp consi...

We present a high-throughput continuous-flow C. elegans sorting device that works based on integrated optical fiber detection and laminar flow switching. Two types of genetically engineered nematodes are allowed to flow into the device and their genotypes are detected based on their fluorescence, without the need for immobilization, by integrated optical fibers. A novel dynamic fluidic switch s...

This work describes the intimate fusion of microsystems and physiology though the implantation of a microfluidic device into living insects. Specifically, we focus on the control of Manduca sexta moth flight activity using an implanted, low power electrokinetic drug delivery device. This effort is a critical component in our development of “Insect Micro-Air-Vehicles” which aim to fuse nanodevic...

The combinatorial synthesis of 2-aminophenoxazin-3-one (APO) in a microfluidic device is reported. Individual microfluidic chips containing metallic zinc, silica-immobilized hydroxylaminobenzene mutase and silica-immobilized soybean peroxidase are connected in series to create a chemo-enzymatic system for synthesis. Zinc catalyzes the initial reduction of nitrobenzene to hydroxylaminobenzene wh...

Zygomatico-orbital fractures are a frequent sequel to trauma of the facial skeleton. The treatment of these fractures is various, depending on their clinical and radiological pictures. The authors describe these methods of positioning and immobilization of zygomatico-orbital fractures that have been used for years. In this context, the Jankowski’s frame and its subsequent modifications should b...

Currently the research about large quantities cells assembly is seriously regarded, since it can provide high efficiency methods for artificial tissue engineering. In this paper, we report a cell assembly method based on cell immobilization by photo-crosslinkable resin and microfluidic self-assembly inside microfluidic devices. The on-chip fabrication of movable microstructures embedding yeast ...

CONTEXT When cervical spine injuries are suspected, the cervical spine should be immobilized in a neutral position and neck motion controlled in preparation for transport to an emergency facility. Protocols for emergency transport utilizing common devices (cervical collars) and methods (transfer techniques) during these procedures are not entirely evidence based. EVIDENCE ACQUISITION The medi...

Background: In head and neck radiotherapy, immobilization devices can affect dose delivery. In this study, a comprehensive end-to-end test was developed to evaluate the accuracy of radiotherapy treatment. Materials and Methods: An Alderson Radiation Therapy (ART) anthropomorphic phantom with EBT3 film was used to mimic the actual patient treatment process. Ten patients treated for nasopharyngea...