Immune-mediated hemolytic anemia (IMHA) is a condition in which autoantibodies bind to endogenous antigens on the erythrocyte membrane, leading to complement or antibody mediated red blood cell destruction. These antigens can be created as part of the normal immune response to an abnormal antigen (i.e. band-3, peroxiredoxin-2, or epitope created by an infectious disease) or due to an abnormal i...

A basic leucine zipper transcription factor, NF-E2-related factor 2 (Nrf2), plays a critical role in the cellular defense mechanism by mediating a coordinate up-regulation of antioxidant responsive element-driven detoxification and antioxidant genes. Here, we report that targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia due to increased sequestration of damaged er...

in this study, a 2.5-year-old boy suffering from a febrile seizure with normal laboratory tests and a history of immune hemolytic anemia was examined. brain mri demonstrated some tumors in the frontal, parietal, and occipital lobe that corroborated the pathology results of primary central nervous system lymphoma for the patient. the patient was treated with high- dose of methotrexate. our resul...

Differential Diagnosis of Hemolytic Anemia Hemolytic anemia reflects shortened RBC life span due to intravascular, extravascular, or fragmentation hemolysis. Intravascular hemolysis is primarily associated with type 1 hypersensitivity reactions, either idiopathic or secondary to another primary disease. In some cases an infectious intraerythrocytic or epierythrocytic agent or miscellaneous diso...