Imunitní trombocytopenie (ITP) je onemocnění charakterizované izolovanou trombocytopenií bez jiných abnormalit v krevním obraze a nátěru. ITP u dětí se dělí do 2 kategorií. Primární získané známé příčiny. Sekundární dítěte vyskytuje jako součást jiného základního onemocnění. Podle délky trvání můžeme rozdělit na nově diagnostikovanou (do 3 měsíců), pe...

BACKGROUND AND OBJECTIVE Flow cytometry (FC) to identify platelet-associated (PA) immunoglobulin (Ig) is a potentially useful diagnostic test for idiopathic thrombocytopenic purpura (ITP). However, the restricted application of PAIg measurement to thrombocytopenic populations primarily comprised of ITP patients will artificially enhance the test's diagnostic specificity. For this reason, we per...

OBJECTIVE To evaluate potential risk factors, presenting symptoms, management, and outcomes of intracranial haemorrhage in Chinese children with immune thrombocytopenia managed in a regional hospital. DESIGN Retrospective case series. SETTING A regional hospital in Hong Kong. PATIENTS All paediatric patients with immune thrombocytopenia complicated by intracranial haemorrhage in the perio...

hepatitis a infection is usually a self–limited disease during childhood. autoimmune manifestations are rarely reported among patients with ha infection. we describe a previously healthy 6-yr-old male with acute hepatitis a who developed immune thrombocytopenia.

BACKGROUND Vancomycin has only rarely been implicated as a cause of thrombocytopenia, and there is only limited evidence that this complication is caused by immune mechanisms. We conducted a study to determine whether thrombocytopenia is caused by vancomycin-dependent antibodies in patients being treated with vancomycin. METHODS We identified and characterized vancomycin-dependent, platelet-r...

Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia. The in...

The common reported adverse impacts of COVID-19 vaccination include the injection site’s local reaction followed by various non-specific flu-like symptoms. Nevertheless, uncommon cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) following viral vector vaccines (ChAdOx1 nCoV-19 vaccine, Ad26.COV2 vaccine) have been reported. This liter...

As with most reports of splenectomy for immune thrombocytopenia, the recent study claiming efficacy of splenectomy for human immunodeficiency virus (HIV)-related thrombocytopenia is uncontrolled, and combines responses of more and less severely thrombocytopenic patients.' In addition, important information is omitted. What were the mean platelet count increases, partial versus complete response...