BACKGROUND Bwamba virus (Genus Bunyavirus, family Bunyaviridae) is widely distributed in Africa. It causes many unidentified fevers because of its benign nature. OBJECTIVES Samples of blood from patients were received at Uganda Virus Research Institute for diagnosis and confirmation of infections. Mosquito collections obtained in the O'nyong-nyong virus fever epidemic in Rakai in 1997 were al...

Epidermal growth factor receptor inhibitors(EGFRi) and Mitogen Activated Kinase inhibitors(MEKi) induce a folliculitis in 65-80% of patients, but it is unclear how they impact on the human hair follicle(HF). We have asked whether EGFRi/MEKi-induced associated with damage HFs immune privilege(IP) excessive HF secretion pro-inflammatory mediators. Scalp biopsies were taken from EGFRi-treated pati...

Dense granule protein (GRA) is a secreted protein in Neospora caninum and Toxoplasma gondii, which plays an important role in forming parasitophorous vacuole (PV) [1–4]. GRAs are thought to remodel and maintain the environment of the PV for intracellular survival and replication in T. gondii [5]. The precise function of GRAs is still unknown [6–9]. TgGRA14 protein is a new GRA protein that it i...

Background. There is no specific data on the pathological lesions underlying idiopathic nephrotic syndrome (INS) in adolescents in Pakistan. Moreover, it is not known whether the pathological lesions in adolescents differ significantly from young children with INS in our setup. Materials and methods. A retrospective analysis was carried out on all patients with INS with onset 18 years of age. T...

Farnesyl diphosphate synthase (FPPS: EC2.5.1.10), a key enzyme in isoprenoid metabolic pathways, catalyzes the synthesis of farnesyl diphosphate (FPP) an intermediate in the biosynthesis of both sterol and non-sterol isoprenoid end products. The localization of FPPS to peroxisomes has been reported (Krisans, S. K., J. Ericsson, P. A. Edwards, and G. A. Keller. 1994. J. Biol. Chem. 269: 14165;-1...

BACKGROUND & OBJECTIVE Respiratory viral infections have a major impact on public health. Acute respiratory infections largely caused by viruses, are the most common illnesses experienced by otherwise healthy adults and children. Among the respiratory viruses, influenza viruses are known to cause outbreaks globally. Information on the activity of influenza virus in our country is limited and no...

The anti-resorptive agent zoledronic acid inhibits key enzymes in the mevalonate pathway, disrupting post-translational modification and thereby correct protein localization and function. Inhibition of prenylation may also be responsible for the reported anti-tumour effects of zoledronic acid, but the specific molecular targets have not been identified. Cenp-F/mitosin, a kinetochore-associated ...

BACKGROUND HER2-targeted therapy with the monoclonal antibody trastuzumab (Herceptin) has improved disease-free survival for women diagnosed with HER2-positive breast cancers; however, treatment resistance and disease progression are not uncommon. Current data suggest that resistance to treatment in HER2 cancers may be a consequence of NF-kappaB overexpression and increased COX2-derived prostag...

PURPOSE BLID is a BH3-like motif containing apoptotic member of the Bcl-2 family of proteins. This study was designed to investigate the mechanism of BLID-induced apoptosis and to assess the significance of BLID expression in breast cancer. EXPERIMENTAL DESIGN The interaction between BLID and Bcl-X(L) was examined using in vitro transcription/translation, coimmunoprecipitation, and immunoflou...