نتایج جستجو برای: immunoglobulin deficiencies
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The posters presented at the Sixth International Immunoglobulin Symposium covered a wide range of fields and included both basic science and clinical research. From the abstracts accepted for poster presentation, 12 abstracts were selected for oral presentations in three parallel sessions on immunodeficiencies, autoimmunity and basic research. The immunodeficiency presentations dealt with novel...
MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency locus, which contains an ortholog of miR-155, miR-K12-11, complements B cell deficiencies in miR-155 knockout mice. Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer'...
Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody-antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas "pure" biochemical approaches have been far less prominent, but change appears imminent. Here we comment on how, when, and why biochemistry is l...
Expression of selected genes in hematopoietic stem cells has been identified as a regulator of differentiation of B cells in the liver and bone marrow. Moreover, naïve B cells expressing surface immunoglobulin need other types of genes for antigen-dependent development in secondary lymphoid organs. Many advanced molecular mechanisms underlying primary antibody deficiencies in humans have been d...
background and purpose: although molds are regarded as the main fungal allergen sources, evidence indicates that spores of basidiomycota including agaricus bisporus (a. bisporus) can be also found at high concentrations in the environment and may cause as many respiratory allergies as molds. the aim of the present study was to evaluate specific immunoglobulin e (ige) and immunoglobulin g (igg) ...
Intravenous immunoglobulin (IVIg) treatment was introduced as replacement therapy for patients with antibody deficiencies, but evidence suggests that a wide range of immune-mediated conditions could benefit from IVIg. The immunoglobulins are precipitated from human plasma by fractionation methods. In conclusion, the differences in basic fractionation methods and the addition of various modifica...
Primary immune deficiencies are a heterogeneous group of inherited disorders in which dysfunctions of the immune system cause an enhanced susceptibility to infections. Their frequency is higher in Tunisia and the Maghreb as compared to European and North American countries. Indeed, our population is characterized by a high frequency of consanguineous marriages and this may account for the highe...
predominantly antibody deficiencies are a category of primary immunodeficiency diseases, which consist of several rare disorders such as common variable immunodeficiency (cvid) and x-linked agammaglobulinemia (xla). we evaluated the effects of cvid and xla patients’ sera as a source of microenviromental factors on maturation and function of monocyte-derived dcs. blood was collected from 10 cvid...
We recommend that routine screening of sera for immunoglobulin disorders consist of a combination of electrophoresis in agarose and immunochemical quantitation of serum lgG, IgA, and 1gM. Abnormalities detected by this procedure may be classified as (a) immune deficiencies, (b) polyclonal hyperimmunoglobulinemias, or (c) monoclonal immunoglobuli n disorders. The analyst can contribute to the di...
Antibody deficiency is the most frequently encountered primary immunodeficiency disease (PIDD) and patients who lack the ability to make functional immunoglobulin require life-long replacement therapy to prevent serious bacterial infections. Human serum immunoglobulin manufactured from pools of donated plasma can be administered intramuscularly, intravenously or subcutaneously. With the advent ...
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