Introduction: cyclooxygenase-2 (COX-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including malignant melanoma; however, there is not enough information about COX-2 expression in benign melanocytic lesions. In the present study we compared the expression levels of COX-2 in malignant melanoma and benign melanocytic lesions. Method: In this analytical study, ...

BACKGROUND Selective immunostaining for calretinin labels the innermost layer of the outer root sheath of normal hair follicles, which is difficult to distinguish with hematoxylin-eosin staining. OBJECTIVE The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the out...

Objectives. Beginning in 2014, the Society of Gynecologic Oncology and American College Obstetricians Gynecologists have recommended universal tumor testing for mismatch repair deficiency endometrial cancer. Mismatch can triage patients who may benefit from genetic Lynch syndrome. Many women previously diagnosed with cancer not undergone testing. We sought to determine feasibility retroactive a...

CONTEXT The increasing demand for immunohistochemistry for clinical diagnostics, in combination with an ongoing shortage of staff in the histology laboratory, has brought about a need for automation in immunohistochemistry. The current automated staining platforms vary significantly in their design and capabilities. OBJECTIVE To review how technology has been applied to automating the process...

The study of placental lactogen by immunohistochemistry in histological sections the placenta during physiological pregnancy and on background iron deficiency anemia aspect chronic insufficiency. It is established that gestation against decreases production syncytiotrophoblast chorionic villi correlates with state blood pregnant woman. optical density immunohistochemical staining for free troph...

Polycystic kidney disease (PKD) is an inherited commonly reported in cats, but rarely big cats. It associated with formation of cysts the kidneys. This article describes clinical, pathology and immunohistochemistry findings PKD a Siberian hybrid tiger. A 16-year-old female captive tiger showed inappetence, weight loss, polyuria, polydipsia. Within six months, its body hydration status were prog...

background and objectives: uterine smooth muscle tumors are the most common human neoplasm .they are divided clinically as benign and malignant but there is  another group of  lesions which is difficult to place in these two categories ,so-called smooth  muscle tumors of uncertain malignant potential (stump) and differentiation  of these tumors on the basis of h&e staining is impossible . t...

OBJECTIVE To observe the role of p63 staining in evaluation of morphologically ambiguous lesions of prostate. STUDY DESIGN Descriptive (case series) study. PLACE AND DURATION OF STUDY Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from March to September 2010. METHODOLOGY p63 immunohistochemistry staining was performed on 30 cases diagnosed as morphologically ambiguo...