A new approach has been developed to fabricate tough hybrid hydrogels by employing dual enzyme-mediated redox initiation to achieve post-self-assembly cross-linking polymerization. The resulting hydrogel combines the merits of supramolecular hydrogels with polymeric hydrogels to achieve higher mechanical strength and porous networks. Designed 3D constructs were fabricated via in situ 3D printin...

Forming hydrogels with precise geometries is challenging and mostly done using photopolymerization, which involves toxic chemicals, rinsing steps, solvents, bulky optical equipment. Here, we introduce a new method for in situ formation of well-defined geometry sealed microfluidic chip by interfacial polymerization. The the hydrogel programmed design capillary pinning structures bringing into co...

The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188 (GEL1, relative hydrophobic) or 6% poloxamer 188 (GEL2, relative hydrophilic), were compared with respect to the rheological properti...

Chitosan-beta glycerophosphate-hydroxyethyl cellulose (CH-GP-HEC) is a biocompatible and biodegradable scaffold exhibiting a sol-gel transition at 37°C. Chondrogenic factors or mesenchymal stem cells (MSCs) can be included in the CH-GP-HEC, and injected into the site of injury to fill the cartilage tissue defects with minimal invasion and pain. The possible impact of the injectable CH-GP-HEC on...