The global population of multimorbid older people is growing steadily. Multimorbidity is the principal cause of complex polypharmacy, which in turn is the prime risk factor for inappropriate prescribing and adverse drug reactions and events. Those who prescribe for older frailer multimorbid people are particularly prone to committing prescribing errors of various kinds. The causes of prescribin...

BACKGROUND Inappropriate use of antibiotics promotes antibiotic resistance. Little is known about physician characteristics that may be associated with inappropriate antibiotic prescribing. Our objective was to assess whether physician knowledge, time in practice, place of training and practice volume explain the differences in antibiotic prescribing among physicians. METHODS A historical coh...

OBJECTIVE To elicit prescribers' preferences for behavioural economics interventions designed to reduce inappropriate antibiotic prescribing, and compare these to actual behaviour. DESIGN Discrete choice experiment (DCE). SETTING 47 primary care centres in Boston and Los Angeles. PARTICIPANTS 234 primary care providers, with an average 20 years of practice. MAIN OUTCOMES AND MEASURES Re...

BACKGROUND Adverse drug-related events are common in the elderly, and inappropriate prescribing is a preventable risk factor. Our objective was to determine whether inappropriate prescribing could be reduced when primary care physicians had computer-based access to information on all prescriptions dispensed and automated alerts for potential prescribing problems. METHODS We randomly assigned ...

IMPORTANCE Interventions based on behavioral science might reduce inappropriate antibiotic prescribing. OBJECTIVE To assess effects of behavioral interventions and rates of inappropriate (not guideline-concordant) antibiotic prescribing during ambulatory visits for acute respiratory tract infections. DESIGN, SETTING, AND PARTICIPANTS Cluster randomized clinical trial conducted among 47 prim...

OBJECTIVES Compared to the general population, chronic kidney disease patients are more vulnerable to gastrointestinal haemorrhage and its morbidity and mortality. Due to the fear of gastrointestinal bleeding consequences in these patients on the one hand, and the perception of general safety of acid suppressive medications on the other hand, inappropriate stress ulcer prophylaxis (SUP) seems t...

BACKGROUND Ageing has become a worldwide reality and presents new challenges for the health-care system. Research has shown that potentially inappropriate prescribing, both potentially inappropriate medications and potentially prescribing omissions, is highly prevalent in older people, especially in the nursing home setting. The presence of potentially inappropriate medications/potentially pres...

drug utilization evaluation (due) is an effective program to identify variability in drug use and to support interventions that will improve patient outcomes. the appropriate use of enoxaparin, a low molecular weight heparin (lmwh), which is widely used as curative or preventive treatment of thromboembolic disorders was assessed in the study. a prospective due was carried out at masih daneshvar...