Cannabis/cannabinoid and bonsai, which is a synthetic derivative of cannabis, are ever increasing public health problems, particularly in adolescents and young adults. Cannabis and its synthetic derivatives have cardiovascular side effects, including myocardial infarction (1, 2). We hereby reported a case of sudden cardiac arrest due to ST elevation myocardial infarction (MI) developing after 4...

Cannabis use is steadily rising in the United States. As the popularity of marijuana rises, new varieties of cannabis-related products are becoming available. Dabs are cannabis concentrates gaining notoriety for their significant amounts of tetrahydrocannabinol (THC) that are ultimately vaporized and inhaled for their effect. Herein, we provide an overview of recent cases of dabbing to bring aw...

For thousands of years, cannabis and its derivatives have been used for the treatment of human diseases including those that present with gastrointestinal (GI) symptoms. Within the past decades and after the discovery of the endocannabinoid system in the body, largely anecdotal rather than scientific reports on the effects of cannabis in human diseases began to appear and resulted in clinicians...

Increases in mesolimbic dopamine transmission are observed when animals are treated with all known drugs of abuse, including cannabis, and to conditioned stimuli predicting their availability. In contrast, decreases in mesolimbic dopamine function are observed during drug withdrawal, including cannabis-withdrawal syndrome. Thus, despite general misconceptions that cannabis is unique from other ...

There is increasing interest in the therapeutic potential of cannabis-based medicinal extracts in multiple sclerosis. Cognitive deficits that have been attributed to long-term heavy recreational use of cannabis are not necessarily extended to controlled pharmaceutical use of cannabis-based medicinal extracts. Available data indicate that after relatively short-term administration of cannabis-ba...

Elevated schizotypy relates to similar cognitive attenuations as seen in psychosis and cannabis/polydrug use. Also, in schizotypal populations cannabis and polydrug (including licit drug) use are enhanced. These cognitive attenuations may therefore either be a behavioral marker of psychotic (-like) symptoms or the consequence of enhanced drug use in schizotypal populations. To elucidate this, w...

While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individ...

Animal and human research suggests that adolescent exposure to cannabis carries a particularly high risk for a range of negative outcomes, including psychosis-related symptoms, cognitive impairment, and substance use problems1-5. Findings of heightened risk associated with adolescent cannabis use, coupled with research pointing to a role of the endocannabinoid system in regulating neurodevelopm...

OBJECTIVES To assess Minnesota pharmacists' preparedness for the state's medical cannabis program in terms of professional competency in policies and regulations and in pharmacotherapy, as well as their concerns and perceptions about the impact on their practice. The secondary objective was to identify pharmacists' perceptions about ways to reduce potential gaps in knowledge. METHODS A Web-ba...

BACKGROUND There are few valid clinical assessment instruments for cannabis. Self-efficacy, or the ability of users to resist temptation, is a central feature of social cognitive theory. This study outlines the development and validation of the cannabis refusal self-efficacy questionnaire (CRSEQ), which measures the situational confidence to refuse cannabis. METHOD One thousand two hundred an...