Since the approval of imatinib in 2001, kinase inhibitors have revolutionized cancer therapies. Inside this family of phosphotransferases, casein kinase 2 (CK2) is of great interest and numerous scaffolds have been investigated to design CK2 inhibitors. Recently, functionalized indeno[1,2-b]indoles have been revealed to have high potency against human cancer cell lines such as MCF-7 breast carc...

       A series of novel indeno[1, 2-b]quinoxalin-11-ylidenamines 2-9 have been synthesized via condensation of indane[1, 2-b]quinoxalin-11-one (1) with various primary aromatic amines in presence of AcOH for 3 h. Compound 1 was synthesized by condensation of indane-1,2,3-trione with benzene-1,2-diamine in presence of AcOH. The synthesized compounds were characterized by IR, 1H-NMR, ...

Recently, magnetic iron oxide nanoparticles functionalized with various organic groups increasing attention in the synthesis of compounds. In this study, ionic liquid nano-magnetic pyridinium-tribromide (MNPs@SiO2-Pr-AP-tribromide) as a new nano-catalyst was synthesized. The structure catalyst identified by FT-IR, TGA, XRD, FE-SEM, EDX, EDS, TEM and VSM analysis. efficient for quinoline derivat...

Dibenzopyracylene (indeno[l ,2,3-cdjfluoranthene) (4) is of theoretical interest due to its electron system, which is regarded as a perturbed [12]annulene [4]. 4 wras only accessible by a multistep synthesis starting from fluoranthene [5]. It was also isolated in traces from the tar formed by pyrolysis of several low molecular compounds [6]. According to the results [3, 7, 8] of the CO eliminat...

Although the quinoline ring is found in a wide variety of biologically active compounds and is frequently condensed with various heterocycles, synthesis and biological evaluation of the indenoquinoline skeleton attracts only very limited attention. We report herein the synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives against the growth of six cancer cell ...

In the mol-ecule of the title compound, C(21)H(20)ClN, the quinoline group is nearly planar and is oriented at a dihedral angle of 77.21 (3)° with respect to the phenyl ring. The conformation of the cyclooctane ring is twist-boat. In the crystal structure, there are some weak π-π inter-actions [centroid-to-centroid distances of 3.7414 (11) and 3.8633 (12) Å] between the rings of the quinoline g...

Tetrahydro-1H-benzo[b]azonin-2,7-dione (2a) has been used as a precursor in the synthesis of dibenzo[b,f ][1,5]diazacyclododecene and dibenzo[b,g][1,6]diazacyclododecene ring systems 4 and 5, respectively, via periodate oxidation of the appropriate indolo-benzo[b]azonines 3 and 7. The synthesis of hexahydro-benzo[b][1,4]diazecin-2,7-dione (10) has been achieved by the Schmidt reaction of 2a. Th...

a series of novel indeno[1, 2-b]quinoxalin-11-ylidenamines 2-9 have been synthesized via condensation of indane[1, 2-b]quinoxalin-11-one (1) with various primary aromatic amines in presence of acoh for 3 h. compound 1 was synthesized by condensation of indane-1,2,3-trione with benzene-1,2-diamine in presence of acoh. the synthesized compounds were characterized by ir, 1h-nmr, mass spectra and e...

The nitrogen-containing indeno[1,2-b]quinoxaline ring is a privileged structurally fused active system and has notable applications in various fields of chemistry.

In the title compound, C(16)H(12)N(2)O(3), the planar quinoline ring system [maximum deviation = 0.025 (3) Å] is oriented at a dihedral angle of 61.76 (7)° with respect to the benzene ring. In the crystal structure, inter-molecular C-H⋯O inter-actions link the mol-ecules into chains parallel to the b axis. π-π contacts between the quinoline rings [centroid-centroid distance = 3.623 (1) Å] may f...