Sepsis is one of the major causes of death reported in intensive care units. Acute kidney injury (AKI) and hypotension are important in the pathogenesis and mortality of systemic inflammatory response (SIR). Sesamol delays mortality in sepsis; however, its effects on AKI and hypotension and the role of peroxisome proliferator-activated receptor-ɣ (PPAR-γ) activation have not been established. W...

Sepsis is one of the major causes of death reported in intensive care units. Acute kidney injury (AKI) and hypotension are important in the pathogenesis and mortality of systemic inflammatory response (SIR). Sesamol delays mortality in sepsis; however, its effects on AKI and hypotension and the role of peroxisome proliferatoractivated receptor-γ (PPAR-γ) activation have not been established. We...

The cerebrovasculature dilates or constricts in response to acute blood pressure changes to stabilize cerebral blood flow across a range of blood pressures. It is unclear, however, whether such dynamic cerebral autoregulation (dCA) is equally effective in responding to falling versus rising blood pressure. In this study we applied a pharmacological approach to evaluate dCA gain to transient hyp...

Autoregulation is the term used to describe the maintenance of constant perfusion over a range of arterial pressures. Autoregulation occurs in all vascular beds, but other mechanisms also act on vascular control, for example autonomic activity and plasma concentrations of hormones. The influence of these other mechanisms varies widely between different circuits, so that the effect of induced hy...

The purpose of this study was to investigate the effects of electroacupuncture (EA) on aqueous humor dynamics in rabbits. EA stimulation was performed through two acupuncture needles placed in close proximity to the sciatic nerve. The sites of needle entry were anesthetized. After 1 hr of EA stimulation, intraocular pressure (IOP) decreased and was accompanied by reductions of blood pressure an...

Since Enderby (1950) first described the use of pentamethonium for a temporary reduction of blood pressure in order to prevent excessive bleeding during surgical operations, only one report of the application of methonium compounds in orthopaedic surgery has appeared (Steven and Tovell 1954). A review of figures concerning blood loss and post-anaesthetic progress in 407 operations performed wit...