Background: Extend of lung injury, inflammation due to SARS COV-2 can also cause liver injury. Liver injury in COVID-19 patients be caused by the direct effect on liver, cholangiocyte role, activation immune system, drug-induced and hypoxic Hepatocyte necrosis could increase transaminase. Therefore, transaminase may reveal severity. Aim: This study aims know relationship severity mortality pati...

Background: Long-term use of levofloxacin can cause alterations in the liver function. This study aimed to determine the protective effect of black seed oil (BSO) against liver injury due to levofloxacin administration in rats. Methods: The chemical composition of BSO was analyzed with gas chromatography and mass spectrophotometry (GC-MS). Rats (n=30) were treated daily with levofloxacin and ...

Mitochondrial injury contributes to severe drug-induced liver injury. Particularly, mitochondrial permeability transition (MPT) is thought be relevant cytolytic hepatitis. However, the mechanism of MPT unclear and prediction not adequately evaluated in preclinical stage. In a previous study, we found that troglitazone, drug withdrawn due injury, induced via mild depolarization probably resultin...

Excessive ethanol intakes have been reported to be linked liver diseases such as hepatitis and cancerrelated of ethanol. can lead the accumulation reactive oxygen species(ROS) depletion glutathione (GSH) in liver. Ethanol-induced oxidative stress substantiallyincreases peroxidation lipid decreases GSH levels human hepatocyte animal models.Ethanol contributes sterol regulating element-binding pr...

Background & Aim: The human body has the liver as one of its largest organs. It serves as the major site for metabolism and excretion. Injury to the liver or impairment of its functions may complicate one’s health and therefore, constitutes one of the serious public health challenges. The ethanol seed extract of Citrus paradisi Macfad (CPE) was carried out to evaluate ...

Mammea africana Sabine (Guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. The hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, to...

We investigated the effect of an albumin infusion on enzyme activity, expression level cytochrome P450 2E1 (CYP2E1), and oxidative stress in serum liver streptozotocin (STZ)-induced diabetic rats. The STZ treatment enhanced alanine aminotransferase aspartate activities rat compared with those untreated Treatment elevated catalytic activity CYP2E1, stress, decreased reducing potentials liver, su...

• A MIF antagonist, ISO-1, protected mice from acute acetaminophen (APAP)-induced liver injury. The effect of ISO-1 may be involved in the recover GSH depletion and inhibition up-regulation RIPK3 kinase following oxidative stress by APAP liver. As an additional on APAP-liver injury, inhibit development further expansion excessive neutrophilic responses. Overdose use (APAP) often occurs a severe...

BACKGROUND Lamivudine is a nucleoside analogue antiretroviral drug, known for its low toxicity at clinically prescribed dose. However, the toxicity or mechanism of toxicity and target tissue effects during prolonged administration of higher doses were hardly given sufficient laboratory attention. AIM The present work was designed to investigate the biochemical and histopathological changes in...