Today, multiple myeloma (MM) can be defined as a heterogenous disease composed of different clinical conditions. The differences are a result of patient related factors (age, sex, comorbidity), disease related complications (renal failure, bone disease, neuropathy, throm‐ bosis) and biological characteristics (cytogenetics, lactate dehydrogenase level, plasma cell labelling index, beta2-microgl...

In most hematologic malignancies the role of induction treatment is to achieve complete remission (CR). In multiple myeloma this has been possible only with the introduction of high-dose therapy plus autologous stem-cell transplantation (ASCT). In the context of ASCT there is a statistical relationship between CR or very good partial remission (VGPR) achievement and progression-free survival or...

BACKGROUND The outcomes of previous trials of mycophenolate mofetil (MMF) in treating severe lupus nephritis (LN) are not in exact agreement. This meta-analysis of randomized controlled trials (RCTs) assesses the benefits and harms of MMF in the induction and maintenance therapy of severe LN. METHODS We searched Medline, EMBASE and the Cochrane Collaboration Database for RCTs that compared MM...

Induction therapy followed by definitive chemoradiotherapy (CRT) has emerged as an option for the treatment of patients with locally advanced squamous cell carcinoma of the head and neck. In this setting, the most studied induction regimen is docetaxel, cisplatin, and 5-fluorouracil (TPF). However, the role of induction therapy remains to be fully validated by studies comparing TPF followed by ...

Abstract Background and Aims Antibody induction therapy is frequently used as an adjunct to the maintenance immunosuppression in adult kidney transplant recipients (KTRs). There are few comparisons of antibody allowing early glucocorticoid withdrawal KTRs. The purpose present study was compare involving tocilizumab with most commonly regimens patient populations at either high immunologic risk ...

Our two meta-analyses show that antilymphocyte antibody induction therapy extends allograft survival when compared to induction therapy with cyclosporine, azathioprine, and prednisone with the majority of the benefit seen during the first 2 years after transplant. The benefit of induction therapy with respect to allograft survival is particularly important among patients with pretransplant pane...

The article was first report a case of a 32-year-old female with NPC that is G6PD-deficient. The patient completed induction chemotherapy and concomitant chemoradiotherapy successfully. The patient experienced grade 1 neutropenia , grade 1 diarrhea, and grade 2 acne-like skin reactions during the three cycles of  induction chemotherapy. Grade 1 neutropenia, grade 1 diarrhea, grade 2 oral mucosi...