This epileptic disorder has become a classic topic for neuropediatricians and the interest is documented by the large number of publications on this subject.The relative frequency among the epileptic syndromes is an another reason why not only neuropediatricians but also general pediatricians must be fully informed about diagnostic, clinical, imaging and genetic aspects.Early diagnosis is of pa...

Infantile spasms associated with brain tumors have been reported. A focal cortical lesion can induce infantile spasms by triggering the brainstem and basal ganglia in this vulnerable age group. We report the case of a female infant with a low-grade glioma in the right basal ganglia, spreading to the cortical area. She presented at the age of five months with left hemiparesis and partial seizure...

Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) have been detected in patients presenting with seizures in the first few months of life and Rett syndrome features. Twenty-seven cases have been detected to date. Generalized intractable seizures, as infantile spasms, and generalized tonic-clonic seizures and myoclonic seizures characterize the clinical picture of CDKL5 mutat...

Background: Infantile Spasms (IS) is a rare epilepsy syndrome with characteristic features, and strong consensus regarding treatment strategies. Clinical care pathways provide standardized evidence-based patient care, support quality improve outcomes. Standardized electronic notes may data collection quality. After the concurrent implementation of an IS pathway note at Alberta Children’s Hospit...

although treated properly for epilepsy, a number of epileptic children have intractable seizures and about 5-10 per cent of them do not respond to anti -epileptic drugs. in the years 1986-1996 about 10,000 epileptic patients were treated in the children's medical center in tehran. a retrospective study of their medical records revealed that 41 of them had intractable seizures. i of these 4...

tuberous sclerosis) (11–13). Therefore, most recently the treatment of WS with valproate has been overtaken and overlooked (14, 15). Overall, the treatment strategies in WS [either the first-line treatments (e.g., ACTH and vigabatrin) or the more classical nongolden treatments (e.g., valproate or other newer anticonvulsants)] are based on the assumption that an early initiation of therapy coupl...