Within the male reproductive system, oxidative stress (OS) has been identified as prevailing etiology of infertility. The effects reactive oxygen species (ROS) on fertility depend dimensions, “modus operandi” ROS and oxido-reduction potential (ORP) tract. Hereupon, for an adequate response to OS, cells our body are endowed with a well-sophisticated system defense in order be protected. Various ...

PURPOSE OF REVIEW This review summarizes the role of free radicals and oxidative stress in the pathophysiology of human reproduction. RECENT FINDINGS An extensive review of the literature on the role of oxidative stress in influencing assisted reproduction and its outcome is described in this article. Free radicals or reactive oxygen species mediate their action through many of the proinflamm...

Background: The role that stress plays in infertility remains controversial and despite medical advances a large percentage of infertility remains unexplained. Clinicians and researchers consistently report that infertile women view infertility and its treatment as extremely stressful. Basic science has elucidated the linkages between the hypothalamic-pituitary axis (HPA) and hypothalamic-pitui...

OBJECTIVE To examine the effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Prospective study. SETTINGS Infertility clinic at a tertiary care academic institution. PATIENT(S) Ninety-two infertile men with normal female partners. Sixteen fertile donors served as the control group. INTERVENTION(S) Standard semen ...