AIMS Cancer stem cell biology is tightly connected to the regulation of the pro-inflammatory cytokine network. The concept of cancer stem cells "inflammatory addiction" leads to envisage the potential role of anti-inflammatory molecules as new anti-cancer targets. Here we report on the relationship between nuclear receptors activity and the modulation of the pro-inflammatory phenotype in breast...

Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy with characteristic skin lesions. Case series have shown an association between dermatomyositis and malignancy. Malignancy has been found in 15-25% of the adult patients with dermatomyositis. A 50-year-old new case of breast cancer, was admitted with muscle weakness and inability to walk. Physical examination revealed fever, perior...

Purpose: Breastfeeding alters the breast microenvironment, and several lines of evidence suggest the breast microenvironment contributes to the clinical phenotype of inflammatory breast cancer. We investigated breastfeeding history as a modifier of locoregional recurrence (LRR), distant metastasis (DM), disease-free survival (DFS), and overall survival (OS) in parous women with inflammatory bre...

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

breast conservation surgery combined with radiation therapy is now an accepted option for the treatment of early breast cancer. so we decided to evaluate the results of such treatment in our first group of patients treated by this method. from 1992 to 1996 , one hundred patients with stage i and ii breast cancer treated with breast conservative surgery (lumpectomy or quadrantectomy). were irrad...

background: interleukin (il)-23 and il-27 are two il-12-related cytokines which their function may dramatically influence the inflammatory response to tumor development. il-12 and il-27 seem to have antagonistic roles with il-23 in tumor site. in this study, il-23 and il-27 mrna expressions were analyzed in peripheral blood of patients with breast cancer and healthy volunteers using quantitativ...

Introduction: Idiopathic Granulomatous Mastitis (IGM) is a rare, debilitating, chronic inflammatory disease of the breast, occurring in women child-bearing age, which can clinically, and radiologically mimic abscess, tubercular infection or breast cancer. Homoeopathy treat by addressing its multifactorial origin, given holistic approach. The paper presents case series 11 patients IGM treated wi...