neuroinflammation is inflammation of the nervous tissue. it be initiated in response to infection, toxic metabolites, auto immunity, traumatic brain injury and variety of causes. exercise is a promising mechanism of prevention and treatment for disease characterized by neuroinflammation. the benefits of exercise and physical activity (pa) are well known and have effects on function of the centr...

We report that N-acetyl-L-cysteine (NAC) treatment blocked induction of TNF-alpha, IL-1beta, IFN-gamma and iNOS in the CNS and attenuated clinical disease in the myelin basic protein induced model of experimental allergic encephalomyelitis (EAE) in Lewis rats. Infiltration of mononuclear cells into the CNS and induction of inflammatory cytokines and iNOS in multiple sclerosis (MS) and EAE have ...

Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system (CNS), destroying the myelin and the axon in variable degrees. The disease is characterized initially by episodes of reversible neurologic deficits. In most patients, these episodes are followed by progressive neurologic deterioration over time. The cause of the disease...

objectives: the study was carried out to assess the analgesic, anti-inflammatory, and cns depressant activity of the methanolic extract of  the lawsonia inermis barks(melib). materials and methods: anti-inflammatory effects of mebli were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. analgesic activity was measured using acetic acid-induced wr...

Curcumin is active component of turmeric and isolated from the rhizome of turmeric, a phenolic natural product. One of inflammatory disease is multiple sclerosis, a multifocal chronic autoimmune inflammatory disease of the CNS, which is also known as a perivascular demyelinating disease. Studies have been shown that neuro-inflammation can have both harmful and beneficial effects on the neuronal...

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of central nervous system (CNS). MS diagnosis and monitoring are mostly based on Magnetic Resonance Imaging (MRI). This study aims to compare a double inversion recovery MRI sequence with fluid-attenuated in Sclerosis brain. A was conducted 75 patients whose aged between 10 70 years who were having brain

Abstract Multiple sclerosis (MS) is an autoimmune neurodegenerative disease mediated by autoreactive Th1 and Th17 cells that migrate into the central nervous system (CNS) target myelin proteins ultimately leading to neuronal damage. Current immunomodulatory treatments reduce severity but do not cure disease, they work for all patients. Recombinant ICs recapitulate anti-inflammatory properties o...

Oligodendrocyte death contributes to the pathogenesis of the inflammatory demyelinating disease multiple sclerosis (MS). Nevertheless, current MS therapies are mainly immunomodulatory and have demonstrated limited ability to inhibit MS progression. Protection of oligodendrocytes is therefore a desirable strategy for alleviating disease. Here we demonstrate that enhancement of the integrated str...

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) associated with inappropriate activation of lymphocytes, hyperinflammatory responses, demyelination, and neuronal damage. In the past decade, a number of biological immunomodulators have been developed that suppress the peripheral immune responses and slow down the progression of the disease. However, once the ...