OBJECTIVES Booster vaccination against 2009 H1N1 influenza virus was recommended for rheumatologic patients under immunosuppressive therapy during the 2009/2010 H1N1 pandemic. In this study we assessed whether B cell depletion with rituximab influences of the antiviral immune response in 2009 H1N1 influenza virus-vaccinated patients. METHODS Influenza virus-specific immune responses were anal...

As pregnant women are at increased risk of influenza infection and influenza-related complications, immunization with inactivated influenza vaccine during the influenza season is recommended. Vaccination during pregnancy is considered to provide benefits for both the mothers and their young infants. In 2009, the novel influenza A (H1N1) virus was reported worldwide to be the cause of a widespre...

background preventing the seasonal or pandemic outbreak of influenza can be powerful and cost-effective. objectives in this study, we constructed a novel virus-like particle (vlp) platform that contains two hemagglutinin (ha) subtypes and evaluated immunogenicity of constructed vlp in mice. materials and methods this recombinant candidate vaccine model resulted in the expression of two has of h...

conclusions vaccination seems to be necessary to prevent this potentially fatal infectious disease. furthermore, timely prescription of antiviral medications is recommended to decrease the risk of severe complications. results the mean age of the women was 28.1 ± 4.7 years with a mean gestational age of 28.7 ± 10.9 weeks. the most common clinical manifestations included coughing (100%), fever (...

BACKGROUND The human B-cell response to natural influenza virus infection has not been extensively investigated at the polyclonal level. METHODS The overall B-cell response of patients acutely infected with the 2009 pandemic influenza A(H1N1)pdm09 virus (A[H1N1]pdm09) was analyzed by determining the reactivity of plasmablast-derived polyclonal antibodies (PPAbs) to influenza proteins. Recipie...

During the 2009–2010 A/H1N1 influenza pandemic, pregnant women infected with the virus experienced excess morbidity and mortality when compared with other groups. Once a vaccine was available, pregnant women were a priority group for vaccination. Only a few studies have reported on the uptake of 2009 A/H1N1 influenza vaccine among pregnant women during the pandemic and none were from Asia. The ...

BACKGROUND Recent pandemics of influenza A H1N1pdm09 virus have caused severe illness, especially in young people. Very few studies on influenza A H1N1pdm09 in post-pandemic periods exist, and there is no information on the severity of both seasonal influenza A(H1N1) and A(H3N2) from the same season, adjusting for potential confounders, including vaccine. METHODS AND RESULTS We performed a re...

BACKGROUND The efficacy of the H1N1 influenza vaccine relies on the induction of both humoral and cellular responses. This study evaluated the humoral and cellular responses to a monovalent non-adjuvanted pandemic influenza A/H1N1 vaccine in occupationally exposed subjects who were previously vaccinated with a seasonal vaccine. METHODS Sixty healthy workers from a respiratory disease hospital...

BACKGROUND Pregnant women are a high-risk group for morbidity and mortality from influenza. During the current pandemic of H1N1 influenza, few cases of H1N1 have been reported in pregnancy. CASES We report two cases of H1N1 influenza which occurred in single institution in the course of one month. The first patient developed acute respiratory distress syndrome, required intubation, and eventu...

Background: Although previous studies have assessed barriers to influenza vaccination in general populations, few studies have assessed barriers among ill persons to inform prevention programs. Methods: We conducted a telephone survey of patients hospitalized with laboratory-confirmed 2009 H1N1infection from December 2009 through April 2010 to evaluate pandemicvaccination coverage and identify ...