Angiotensin II (ANG II)-induced hypertension is a commonly studied model of experimental hypertension, particularly in rodents, and is often generated by subcutaneous delivery of ANG II using Alzet osmotic minipumps chronically implanted under the skin. We have observed that, in a subset of animals subjected to this protocol, mean arterial pressure (MAP) begins to decline gradually starting the...

Infusion devices for continuous and precise drug administration are indispensable tools in anaesthesia and critical care medicine. Problems such as start-up delays, non-continuous flow and susceptibility to hydrostatic pressure changes at low infusion rates resulting in accidental bolus release or prolonged flow interruption are inherent to current infusion technology. In order to improve preci...

We randomized 18 critically ill patients to receive ceftazidime 6 g/day by continuous infusion or bolus dosing (2 g 8 hourly), each with a loading dose of 12 mg/kg ceftazidime. During the first 8 h, plasma ceftazidime concentration fell below 40 mg/L in only one patient (trough 38 mg/L) from the infusion group, compared with eight from the bolus group (2-33 mg/L) for periods ranging from 73 to ...

OBJECTIVE We studied the patterns of digits and numbers used when programming infusion pumps with the aim of informing the design of number entry interfaces. BACKGROUND Number entry systems on medical devices are designed with little thought given to the numbers that will be entered. In other fields, text and number entry interfaces are designed specifically for the task that they will be use...

We propose and demonstrate a pump-phase locking technique that makes use of weak pump depletion (WPD) - an unavoidable effect that is usually neglected - in a sub-threshold optical parametric oscillator (OPO). We show that the phase difference between seed and pump beam is imprinted on both light fields by the non-linear interaction in the crystal and can be read out without disturbing the sque...

Introduction Dynamic susceptibility contrast (DSC) MR perfusion is based on the indicator dilution theorem for non-diffusible tracers.[1,2] A common misconception is that tracer recirculation cannot occur in order to make use of the underlying theory (i.e., analysis of the tracer kinetics must be “firstpass”).[3-13] As a result, there have been a number of approaches suggested for removing trac...

The implantable left ventricular assist system (LVAS) using pulsatile pump technology has become an established therapeutic option for advanced heart failure patients. However, there have been technological limitations in some older designs, including a high incidence of infection and mechanical failures associated with moving parts, and the large size of both implantable pump and percutaneous ...

[This corrects the article on p. 537 in vol. 58, PMID: 20589178.].