Air classifier technology (ACT) is introduced as part of formulation integrated dry powder inhaler development (FIDPI) to optimise the de-agglomeration of inhalation powders. Carrier retention and de-agglomeration results obtained with a basic classifier concept are discussed. The theoretical cut-off diameter for lactose of the classifier used, is between 35 and 15 microm for flow rates ranging...

Deposition and clearance of inhaled particles of iron oxide labeled with (198)Au were studied in 19 normal subjects (10 nonsmokers and 9 smokers). For this purpose, monodisperse aerosols of particles with a 2 mu diameter were produced in a spinning disc atomizer. Thoracic counts and images with a scintillation camera were begun immediately after inhalation of the aerosol and continued for 6 hr....

Adrenomedullin (AM) is a potent vasodilator peptide. We investigated whether inhalation of aerosolized AM ameliorates monocrotaline (MCT)-induced pulmonary hypertension in rats. Male Wistar rats given MCT (MCT rats) were assigned to receive repeated inhalation of AM (n = 8) or 0.9% saline (n = 8). AM (5 mug/kg) or saline was inhaled as an aerosol using an ultrasonic nebulizer for 30 min four ti...

Respiratory foreign body and subsequent inhalant injury in children is a severe emergent disease in otorhinolaryngology. Inhalation injury (usually referred to as “respiratory tract burn”) is mainly caused by aspiration of hot smog, gas, dust and chemical substances into the respiratory tract. The clinical occurrence of respiratory foreign body and inhalation injury in combination is characteri...

We examined for myocardial ischemia induced by continuous inhalation of fenoterol in children with severe acute asthma. Thirty children with severe acute asthma were evaluated for signs of myocardial ischemia when treated with 0.5 mg kg dose (maximum 15 mg) of inhaled fenoterol for one hour. The heart rate was measured before and after inhalation. Cardiac enzymes (creatine kinase, creatine kina...

MURA. Efect of ether anesthesia on r7-hydroxycur~icosteroid secretion in dogs. Am. J. Physiol. rg7(6): 1261-1262. rg5g.--In dogs with previously cut dorsal spinal roots (T1r-L3), adrenal venous blood was collected without anesthetic or pain. Ether was then inhaled for 30-60 minutes. During and after ether inhalation, adrenal venous blood was again collected and the plasma was analyzed for I 7-h...

Pain and urinary symptoms following colorectal cancer (CRC) surgery are frequent and carry a poor recovery. This study tested the effects of inhalation of Lavandula angustifolia Mill. (lavender) oil or linalyl acetate on pain relief and lower urinary tract symptoms (LUTS) following the removal of indwelling urinary catheters from patients after CRC surgery. This randomised control study recruit...

Studies of flow through the human airway have shown that inhalation time (IT) and secondary structures can play important roles in particle deposition. However, effects varying IT conjunction with respiratory rate (RR) on remain unknown. Using three-dimensional numerical simulations oscillatory an idealized model (consisting a mouth, glottis, trachea, symmetric double bifurcation) at trachea Re...