نتایج جستجو برای: inhibitory concentration
تعداد نتایج: 479959 فیلتر نتایج به سال:
Novel BACE-1 inhibitors with a hydroxyethylene central core have been developed. Modified P1´ and extended P1 substituents were incorporated with the aim to explore potential interactions with the S1´ and the S1-S3 pocket, respectively, of BACE-1. Inhibitors were identified displaying IC50 values in the nanomolar range, i.e. 69 nM for the most potent compound. Possible inhibitor interactions wi...
Page 6445. In Table 1, the IC50, pIC50, and LE values of compound 5 are incorrect. They should be 68± 11 nM, 7.2, and 0.89, respectively. The reported values correspond to a different chemical entity; this error was caused by a mislabeling-error in screening of the fragment library. The main text is unaffected by this error. Compound 5 was only discussed as a tolerated structural analogue of co...
recreational waters should be considered as risks for enterococcal infections in regions with high utilization and long exposure periods. the aim of this study was to investigate the resistance of enterococci to selected antibiotics and some heavy metals [pb+2, fe+2, zn+2 and cr+2]. a total of 75 enterococcal isolates was obtained from 54 bathing and fishing water samples from 9 bathing and fis...
background and purpose: candidiasis is a major fungal infection, and candida albicans is the major cause of infections in humans. the clinical and laboratory standards institute (clsi) developed new breakpoints for antifungal agents against c. albicans. in this multi-center study, we aimed to determine the drug susceptibility profile of c. albicans, isolated from iranian population according to...
background: trichomoniasis is the most common nonviral sexually transmitted human disease that is caused by protozoan trichomonas vaginalis. metronidazole is the selective drug in trichomoniasis treatment. however, the reported cases show an increasing trend of drug resistance. this study aimed to evaluate the effect of mango and blueberry extracts on t. vaginalis. materials and methods: t. vag...
conclusions the results showed that enterococci are common contaminants in food. indeed, this study indicates a high prevalence of multidrug-resistant enterococci in food of animal origin in iran. isolating some persisting enterococcal isolates revealed that continuous surveillance of antimicrobial resistance in enterococci from food is essential. materials and methods thirty samples of meat, c...
Cell line cytotoxicity assays have become increasingly popular approaches for genetic and genomic studies of differential cytotoxic response. There are an increasing number of success stories, but relatively little evaluation of the statistical approaches used in such studies. In the vast majority of these studies, concentration response is summarized using curve-fitting approaches, and then su...
A series of 2-N-alkyl-3-aryl-3-alkoxyisoindolinones has been synthesised and evaluated as inhibitors of the MDM2-p53 interaction. The most potent compound, 3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2,3-dihydroisoindol-1-one (NU8231), exhibited an IC50 of 5.3 +/- 0.9 microM in an ELISA assay, and induced p53-dependent gene transcription in a dose-dependent manner, in the S...
Based on a known pharmacophore model for 5-HT₆ receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT₆ receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displayed antagonist profile in 5-HT₆ receptor functional assays. Compounds 2-(4-(2-methoxyphenyl)piperazi...
198 lactic acid bacteria (lab) were isolated from iranian milk samples. almost all isolatedlab showed inhibitory activity towards e. coli and s. aureus as gram negative and grampositive indicators, respectively. no role was observed for hydrogen peroxide in the activity ofall isolated strains while organic acids proved a prominent role in all detected inhibitoryactivities. within isolated lab, ...
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