conclusions regarding clinical and laboratory standards institute (clsi) definition for vancomycin susceptibility (mic < 2 μg/ml), it seems that vancomycin may not be considered as the best antibiotic in order to treat heteroresistant vancomycin intermediate s. aureus (hvisa) and vancomycin sensitive s. aureus (vssa) infections, and a new breakpoint for vancomycin and alternative antibiotics sh...

A synthesis procedure for heteroatom-substituted tetra(3,4-pyrido)porphyrazines that absorb light near 800 nm was developed. Based on the observed relationships between the structure and photophysical parameters, a novel highly photodynamically active (IC50 = 0.26 μM) compound was synthesized and biologically characterized.

In our study, bioactivity of essential oil extracted from Ginger (Zingiber officinaleRoscoe.) that belongs to family Zingiberaceae was analyzed. Ginger rhizome oil was found to be effective against a range of bio-deteriogens. The Minimum Inhibitory Concentration (MIC) value was determined by Poisoned Food Technique and Volatile Activity Assay. The study demonstrates that essential oil had a wid...

Novel BACE-1 inhibitors with a hydroxyethylene central core have been developed. Modified P1´ and extended P1 substituents were incorporated with the aim to explore potential interactions with the S1´ and the S1-S3 pocket, respectively, of BACE-1. Inhibitors were identified displaying IC50 values in the nanomolar range, i.e. 69 nM for the most potent compound. Possible inhibitor interactions wi...

Page 6445. In Table 1, the IC50, pIC50, and LE values of compound 5 are incorrect. They should be 68± 11 nM, 7.2, and 0.89, respectively. The reported values correspond to a different chemical entity; this error was caused by a mislabeling-error in screening of the fragment library. The main text is unaffected by this error. Compound 5 was only discussed as a tolerated structural analogue of co...

recreational waters should be considered as risks for enterococcal infections in regions with high utilization and long exposure periods. the aim of this study was to investigate the resistance of enterococci to selected antibiotics and some heavy metals [pb+2, fe+2, zn+2 and cr+2]. a total of 75 enterococcal isolates was obtained from 54 bathing and fishing water samples from 9 bathing and fis...

background and purpose: candidiasis is a major fungal infection, and candida albicans is the major cause of infections in humans. the clinical and laboratory standards institute (clsi) developed new breakpoints for antifungal agents against c. albicans. in this multi-center study, we aimed to determine the drug susceptibility profile of c. albicans, isolated from iranian population according to...

background: trichomoniasis is the most common nonviral sexually transmitted human disease that is caused by protozoan trichomonas vaginalis. metronidazole is the selective drug in trichomoniasis treatment. however, the reported cases show an increasing trend of drug resistance. this study aimed to evaluate the effect of mango and blueberry extracts on t. vaginalis. materials and methods: t. vag...

conclusions the results showed that enterococci are common contaminants in food. indeed, this study indicates a high prevalence of multidrug-resistant enterococci in food of animal origin in iran. isolating some persisting enterococcal isolates revealed that continuous surveillance of antimicrobial resistance in enterococci from food is essential. materials and methods thirty samples of meat, c...

Cell line cytotoxicity assays have become increasingly popular approaches for genetic and genomic studies of differential cytotoxic response. There are an increasing number of success stories, but relatively little evaluation of the statistical approaches used in such studies. In the vast majority of these studies, concentration response is summarized using curve-fitting approaches, and then su...