Human body mathematical modeling in impact biomechanics was firstly led in order to predict body kinematics and only later to define injury mechanisms. The objective of the undergoing research is to produce numerical tools which are able to predict head injuries. The present study focuses on the injury prediction capability of a numerical head model simulating professional football players who ...

Drug induced liver disease is one of the most important causes of drug withdrawals post marketing. The liver is an engine that creates and stores energy, metabolises and detoxifies chemicals through various pathways, each of which can be a target of liver injury. Corroboration with animal studies is not optimal; pre registration studies do not have sufficient numbers to identify injury causing ...

Toxicology seeks to understand and quantify injurious chemico-biological interactions. The application of this understanding is prediction of the likelihood of occurrence of injury to human health or to undesirable alteration of ecological balance. The key to understanding chemical induced biological injury is development of improved methods of measuring changes in cellular function and structu...

The objective of this study was to verify if replacing the Injury Severity Score (ISS) by the New Injury Severity Score (NISS) in the original Trauma and Injury Severity Score (TRISS) form would improve the survival rate estimation. This retrospective study was performed in a level I trauma center during one year. ROC curve was used to identify the best indicator (TRISS or NTRISS) for survival ...

traumatic brain injury (tbi) is one of the serious neurodisorders commonly caused by car accidents and sports. preventive measures are highly recommended to reduce the risk and number of tbi cases. after tbi, the primary injury to the brain initiates a secondary injury process that spreads via multiple molecular mechanisms in the pathogenesis of tbi. many studies in animals using cdna microarra...

BACKGROUND Virtually all the literature on head injury has focused on the outcome prediction of severe and mild head injuries and very few studies have been dedicated to patients sustaining moderate head injuries. AIM To identify the patient following moderate head injury who may die, develop severe disability or significant cognitive and behavioral problems on the first day of injury itself....

OBJECTIVE To develop a statistically rigorous trauma mortality prediction model based on empiric estimates of severity for each injury in the abbreviated injury scale (AIS) and compare the performance of this new model with the injury severity score (ISS). SUMMARY BACKGROUND DATA Mortality rates at trauma centers should only be compared after adjusting for differences in injury severity, but ...

background: the present study assesses independent predictors of clinically important traumatic brain injury (citbi) in order to design a prognostic rule for identification of high risk children with mild head injury. materials and methods: in a retrospective cross-sectional study, 3,199 children with mild traumatic brain injury (tbi) brought to emergency ward of three hospitals in tehran, iran...