Pseudomonas aeruginosa is the most common gram-negative pathogen causing pneumonia in immunocompromised patients. Acute lung injury induced by bacterial exoproducts is associated with a poor outcome in P. aeruginosa pneumonia. The major pathogenic toxins among the exoproducts of P. aeruginosa and the mechanism by which they cause acute lung injury have been investigated: exoenzyme S and co-regu...

Screening insertional mutants for loss of virulence is an effective method for investigating the molecular genetic basis of bacterial pathogenesis, but has only recently been applied to fungal pathogens. For many pathogenic fungi transformation with heterologous plasmid DNA results in complex integration events. This problem can now be circumvented for some species using restriction enzyme medi...

introduction: bacterial translocation is defined as the passage of bacteria from intestinal tract to the extraintestinal organs such as the peritoneum and blood circulation. the aim of this study is to examine bacterial translocation (regarding type of bacteria and effect of time of obstruction on bacterial translocation) from intestinal lumen to the peritoneum and viscera in acute, simple mech...

URING a study of the arginine-1 locus in Neurospora crmsa, one mutant strain (H4250) was found to produce, on crossing to wild type, an unusual class of progeny. These progeny initially show very slow “inhibited” growth with a characteristic spidery morphology, and are darkly pigmented on complete medium; they are therefore called Dark Agars. After several days, they escape from the inhibition ...

Non-insertional Achilles tendinopathy is a degenerative condition characterised by pain on activity.Eccentric stretching is the most effective treatment.Surgical treatment is reserved for recalcitrant cases.Minimally-invasive and tendinoscopic treatments are showing promising results. Cite this article: Pearce CJ, Tan A. Non-insertional Achilles tendinopathy. EFORT Open Rev 2016;1:383-390. DOI:...

Posterior heel pain is a common condition of the foot and ankle and is seen in a variety of foot types. Nonoperative treatment methods consisting of shoes inserts, heel lifts, stretching, physical therapy, nonsteroidal antiinflammatory drugs, eccentric strength training, and other modalities have been shown to have mixed results. When indicated, surgical repair can produce good long-term result...

Background: Acute Myeloid Leukemia (AML) with translocation (3,3) is a form of AML that may present de novo or may arise from a previous myelodysplastic syndrome. It is often associated with normal or elevated peripheral blood platelet count and increased bone marrow megakaryocytes with associated multi lineage dysplasia. A subset of patients present with hepatosplenomegaly while a few cases h...

The management of recalcitrant patellar tendinopathies in the athletic population can be vexing to both the surgeonand patient. To date the majority of treatments for this disease pathology are non-surgical in nature. When surgicalintervention is required, open debridement and/or tendon take-down with repair has been necessary. We proposea novel technique for the treatment of insertional patell...