We read with great interest the article by Liu et al. (1) demonstrating that progression of diabetes among subjects with latent autoimmune diabetes in adults (LADA) having low titer of GAD antibody (GADA) is similar to that in subjects with type 2 diabetes over the periodof 3 years. This is a largepopulationbased, prospective, well-controlled study with well-characterized subjects. Major epidem...

Background: Inflammatory bowel disease unclassified (IBDU) is considered to be an aberrant immune response with loss of tolerance to many antigens. Objective: This paper tries to address whether there is any value to test for auto-antibodies in such patients. Methods: 60 patients with inflammatory bowel disease unclassified participated in the study. Auto-antibodies to nuclear antigen, intestin...

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W hile insulin antibodies reportedly exist in about half of patients with type 2 diabetes who inject insulin, these antibodies do not often severely affect blood glucose levels (1). Here, we report a patient who had insulin antibodies against human insulin and developed insulin resistance after episodes of frequent hypoglycemic attacks, even though insulin therapy had been discontinued. A 68-ye...

OBJECTIVE We assessed diabetes risk associated with zinc transporter-8 antibodies (ZnT8A), islet cell antibodies (ICA), and HLA type and age in relatives of people with type 1 diabetes with the standard biochemical autoantibodies (BAA) to insulin (IAA), GAD65 (GAD65A), and/or insulinoma-associated protein 2 antigen (IA-2A). RESEARCH DESIGN AND METHODS For this analysis, 2,256 relatives positi...

background: inflammatory bowel disease unclassified (ibdu) is considered to be an aberrant immune response with loss of tolerance to many antigens. objective: this paper tries to address whether there is any value to test for auto-antibodies in such patients. methods: 60 patients with inflammatory bowel disease unclassified participated in the study. auto-antibodies to nuclear antigen, intestin...

The study has now been extended to 22 first degree relatives positive for two or more antibodies among anti-GAD (GADA), anti-IA-2 (IA2A) and anti-insulin (IAA) undergoing a total of 27 six-month periods of a gluten-free diet, followed by an equal number of six-month periods of normal gluten-containing diet. Five subjects developed clinical diabetes during follow-up. In the remainder, first phas...