Insulin has long been hypothesized to cause sodium retention, potentially of enough magnitude to contribute to hypertension in obesity, metabolic syndrome, and Type II diabetes. There is an abundance of supportive evidence from correlational analyses in humans, acute insulin infusion studies in humans and animals, and chronic insulin infusion studies in rats. However, the absence of hypertensio...

Background: Diabetic ketoacidosis (DKA) is an acute metabolic healthcare crisis in patients with diabetes mellitus. The current study aimed to compare the effectiveness of rapid-acting insulin analog administered subcutaneously regular infused intravenously among DKA patients. Methodology: In this prospective open labelled study, 100 consecutive were randomly assigned two groups. Group 1 admit...

Sixty minutes' intravenous glucose infusion tests were carried out in normal subjects, borderline cases, and diabetics which were diagnosed by 50 g oral glucose tolerance test . Infusion was performed at the rate of 5 mg/kg/min . or 15 mg/kg/min. using 5% or 10% glucose. The difference in the insulin responses among thesegroups was rather marked in the case of 15 mg/kg/min. infusion of 10% gluc...

Insulin therapy has enabled patients with diabetes to maintain blood glucose control to lead healthier lives. Today, rather than injecting insulin manually using syringes, a patient can use a device such as an insulin pump to deliver insulin programmatically. This allows for more granular insulin delivery while attaining blood glucose control. Insulin pump system features have increasingly bene...

BACKGROUND The popularity of continuous subcutaneous insulin infusion (CSII), or insulin pump therapy, as a way to deliver insulin more physiologically and achieve better glycemic control in diabetes patients has increased. Despite the substantiated therapeutic advantages of using CSII, its use has also been associated with an increased risk of technical malfunctioning of the device, which lead...

CONTEXT In women with polycystic ovarian syndrome (PCOS), the relationship of insulin to LH secretion and responses to GnRH remains unresolved. A rigorous analytical examination of this relationship has not been performed. OBJECTIVE Our objective was to determine the relationship of basal LH secretion and responses to GnRH, insulin, and other endocrine variables in normal and PCOS women. DE...

To test the hypothesis that insulin acutely enhances the metabolic clearance rate (MCR) of dehydroepiandrosterone in humans, the effect of a short-term insulin infusion on the MCR of dehydroepiandrosterone was assessed in 10 men and 7 women. After an overnight fast, dehydroepiandrosterone was infused at 3.47 mumol/h for 6.5 h. At 240 min, a hyperinsulinemic-euglycemic clamp was begun by infusin...

Teff, Karen L., and Raymond R. Townsend. Early phase insulin infusion and muscarinic blockade in obese and lean subjects. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R198–R208, 1999.—The effect of early phase insulin on postprandial levels of insulin, C-peptide, glucose, and glucagon was investigated in lean (n 5 10) and obese (n 5 12) subjects. Subjects underwent four condi...