pp52 (LSP1) is a leukocyte-speci®c phosphoprotein that binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis. The expression of pp52 is restricted to leukocytes by a 549 bp tissue-speci®c promoter. Here, we show that promoter fragments smaller than the 549 bp pp52 promoter have activity in ...

The bullet, which is activated by the firing of gunpowder in gun silencer, comes out gun's barrel. In meantime, an irritating muzzle blast sound heard that lasts for a few milliseconds. With this explosion, acoustic waves are formed independent bullet's path motion. study, silencer can be attached to low-power 9 mm firearm modeled. Afterward, impact holes with same area drilled different geomet...

Transcriptional regulation of human genes depends not only on promoters and nearby cis-regulatory elements, but also on distal regulatory elements such as enhancers, insulators, locus control regions, and silencing elements, which are often located far away from the genes they control. Our knowledge of human distal regulatory elements is very limited, but the last several years have seen rapid ...

While statin intake has been proven to reduce the risk of colorectal cancer (CRC), the mechanism of antitumor effects and clinical significance in survival benefits remain unclear. Statin-induced antiproliferative effects and its underlying mechanism were examined using six CRC cell lines. Statins except pravastatin showed antiproliferative effects (simvastatin ≥ fluvastatin > atorvastatin) eve...

Internal combustion engines and blowers frequently utilize silencers to reduce exhaust noise. In the current paper, transmission loss of reactive is predicted using plane wave decomposition method a three-dimensional (3-D) time-domain computational fluid dynamics (CFD) approach. A mass-flow-inlet boundary condition first used perform steady flow computation, which serves as an initial for two s...

Abstract The multifunctionality of genome is suggested at some loci in different species but not well understood. Here we identified a DES-K16 region an intron the Kctd16 gene as chromatin highly marked with epigenetic modifications both enhancers (H3K4me1 and H3K27ac) silencers (H3K27me3) mouse spermatocytes. In vitro reporter assay demonstrated that exhibited significant enhancer activity spe...

Homeotic genes are important for early development, but they are subjected to silencing during the later stages. It is known that Polycomb group proteins are involved in this type of distant regulation. The cut locus, a hierarchal regulator of external sensory organs, spans about 220 kb in 7B region on X chromosome. It is important for the normal development at different stages of Drosophila de...

In Saccharomyces cerevisiae, silencers flanking the HML and HMR loci initiate the establishment of transcriptional silencing. We demonstrate that the activity of a silencer pertaining to its potency and directionality is dependent on its genomic position. The context of the HML-E silencer is more permissive to silencer function than that of HML-I or HMR-E, despite that HML-E and HML-I are only ...

Retroviral vectors are transcriptionally silenced in hematopoietic stem cells, and this phenomenon must be overcome for effective gene therapy of blood diseases. The murine stem cell virus (MSCV) vector completely silences beta-globin reporter genes regulated by locus control region (LCR) elements 5'HS2 to 5'HS4 in seven of eight transgenic mice. Here, we show that no single known MSCV silencer...