نتایج جستجو برای: interferon alfa
تعداد نتایج: 81290 فیلتر نتایج به سال:
OBJECTIVE To determine the therapeutic efficacy of interferon alfa-2a in the treatment of Behçet disease. DESIGN A randomized placebo-controlled and double-blind study. SETTING University referral center. PATIENTS Fifty patients with Behçet disease were involved in the study. INTERVENTION The patients were given interferon alfa-2a, 6 x 10(6) IU, subcutaneously 3 times per week or placeb...
OBJECTIVE To test the effect of interferon alfa and tribavirin (ribavirin) in patients with rabies encephalitis. DESIGN An open trial of chemotherapy and intensive care in patients with early rabies. SETTING The intensive care unit of a Bangkok hospital. PATIENTS Four conscious men with clinical rabies encephalitis. INTERVENTIONS Rapid virological diagnosis of rabies. Treatment with int...
OBJECTIVE To assess the efficacy and safety of interferon alfa with or without ribavirin for treatment of chronic hepatitis C. DESIGN Systematic review of randomised trials on interferon alfa plus ribavirin combination therapy versus interferon alfa. Patients were naive (not previously treated with interferon), relapsers (transient response to previous interferon therapy), or non-responders (...
Abbreviations: FCH, fibrosing cholestatic hepatitis; HAV, hepatitis A virus; HBIG, hepatitis B immunoglobulin; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HCV-R, HCV recurrence; HDV, hepatitis D virus; HEV, hepatitis E virus; HVPG, hepatic venous pressure gradient; IgM, immunoglobulin M; LADR, low accelerated dose regimen; LAM, lamivudine; IFNa , interferon al...
BACKGROUND Imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase, produces high response rates in patients with chronic-phase chronic myeloid leukemia (CML) who have had no response to interferon alfa. We compared the efficacy of imatinib with that of interferon alfa combined with low-dose cytarabine in newly diagnosed chronic-phase CML. METHODS We randomly assigned 1106 patients to ...
PURPOSE We aimed to compare the rates of sustained virologic response (SVR) achieved with peginterferon (PEG-IFN) alfa-2a and alfa-2b in combination with ribavinin (RBV) for chronic hepatitis C, using a large database of hepatitis cases to improve the generalizability of these results. METHODS We identified patients with chronic hepatitis C who were treated with PEG-IFN alfa-2a or alfa-2b and...
PURPOSE Recent clinical trials have evaluated treatment strategies for chronic infection with hepatitis C virus (HCV) in patients co-infected with human immunodeficiency virus (HIV). Our objective was to use these data to examine the cost-effectiveness of treating HCV in an urban cohort of co-infected patients. METHODS A computer-based model, together with available published data, was used t...
Forty eight eyes of 42 patients with choroidal neovascular membranes and age-related macular degeneration who received three different dose regimens of systemic interferon alfa-2 were studied retrospectively. The response to treatment of 41 eyes of the 37 patients who received at least 4 weeks' treatment was analysed with respect to the change in size of the choroidal neovascular membrane and t...
Peginterferon alfa plus ribavirin is currently the treatment of choice for chronic hepatitis C. Peginterferon alfa-2a (40KD) plus ribavirin has given an overall sustained virological response of 18% in F3/F4 previous nonresponder US patients. We evaluated the effectiveness of peginterferon alfa-2a (40KD) plus ribavirin in Brazilian patients who were relapsers or nonresponders to previous interf...
BACKGROUND Japanese encephalitis virus (JEV), although confined to Asia, causes about 35000-50000 cases and 10000 deaths every year, and is the most important cause of encephalitis worldwide. There is no known antiviral treatment for any flavivirus. Results from in-vitro studies and work in animals have shown inteferon alfa has antiviral activity on Japanese encephalitis and other flaviviruses;...
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