نتایج جستجو برای: interferon beta 1b

تعداد نتایج: 269096  

Journal: :JAMA neurology 2014
Alberto Ascherio Kassandra L Munger Rick White Karl Köchert Kelly Claire Simon Chris H Polman Mark S Freedman Hans-Peter Hartung David H Miller Xavier Montalbán Gilles Edan Frederik Barkhof Dirk Pleimes Ernst-Wilhelm Radü Rupert Sandbrink Ludwig Kappos Christoph Pohl

IMPORTANCE It remains unclear whether vitamin D insufficiency, which is common in individuals with multiple sclerosis (MS), has an adverse effect on MS outcomes. OBJECTIVES To determine whether serum concentrations of 25-hydroxyvitamin D (25[OH]D), a marker of vitamin D status, predict disease activity and prognosis in patients with a first event suggestive of MS (clinically isolated syndrome...

2016
Ludwig Kappos Gilles Edan Mark S. Freedman Xavier Montalbán Hans-Peter Hartung Bernhard Hemmer Edward J. Fox Frederik Barkhof Sven Schippling Andrea Schulze Dirk Pleimes Christoph Pohl Rupert Sandbrink Gustavo Suarez Eva-Maria Wicklein S Strasser-Fuchs T Berger K Vass C Sindic B Dubois D Dive V Delvaux J Debruyne L Metz G Rice M Kremenchutzky P Duquette Y Lapierre M Freedman A Traboulsee P O'Connor P Stourac R Talab M Valis O Zapletalova I Kovarova E Medova J Fiedler J Frederiksen B Brochet T Moreau P Vermersch J Pelletier G Edan M Clanet B David P Clavelou C Lebrun-Frenay O Gout M Kallela T Pirttila J Ruutiainen JP Erälinna K Koivisto M Reunanen I Keskinarkus I Elovaara A Villringer H Altenkirch L Bauer M Ghazi C Pohl K Wessel H-P Hartung W Steinke B Kieseier H Kolmel P Oschmann M Berghoff R Diem B Kitze A Dressel F Hoffmann K Baum S Jung H Felicitas Petereit D Reske M Sailer J Kohler B Tackenberg L Klotz R Hohlfeld T Kuempfel K-H Henn A Steinbrecher K Angstwurm H Tumani R Gold P Rieckmann C Kleinschnitz R Komoly G Gacs G Jakab G Panczel T Csepany L Csiba L Vecsei A Miller D Karussis J Chapman A Ghezzi G Comi V Martinelli P Gallo V Cosi R Bergamaschi L Durelli P Cavalla CH Polman F Barkhof B Uitdehaag B Anten R Hupperts L Visser K-M Myhr A Szczudlik K Selmaj Z Stelmasiak H Barosik-Psujek R Podemski Z Maciejek S Wawrzyniak L Cunha S Sega-Jazbec X Montalbán T Arbizu A Saiz Hinarejos J Barcena S Martínez Yélamos R Arroyo O Fernandez G Izquierdo Ayuso B Casanova i Estruch J Lycke L Kappos A de Vera S Wu E-W Radue J Kuhle H Mattle K Beer R Coleman DH Miller J Chataway J O'Riordan S Howell HF McFarland J Kesselring AJ Petkau KV Toyka

OBJECTIVE To assess outcomes for patients treated with interferon beta-1b immediately after clinically isolated syndrome (CIS) or after a short delay. METHODS Participants in BENEFIT (Betaferon/Betaseron in Newly Emerging MS for Initial Treatment) were randomly assigned to receive interferon beta-1b (early treatment) or placebo (delayed treatment). After conversion to clinically definite mult...

2015
Georgios Hadjigeorgiou Efthimios Dardiotis Georgios Tsivgoulis Triantafyllos Doskas Damianos Petrou Nikolaos Makris Nikolaos Vlaikidis Thomas Thomaidis Athanasios Kyritsis Nikolaos Fakas Xoulietta Treska Clementine Karageorgiou Stefania Sotirli Christos Giannoulis Dimitra Papadimitriou Ioannis Mylonas Evaggelos Kouremenos George S. Vlachos Dimitrios Georgiopoulos Despoina Mademtzoglou Michalis Vikelis Elias Zintzaras

Georgios Hadjigeorgiou, Efthimios Dardiotis, Georgios Tsivgoulis, Triantafyllos Doskas, Damianos Petrou, Nikolaos Makris, Nikolaos Vlaikidis, Thomas Thomaidis, Athanasios Kyritsis, Nikolaos Fakas, Xoulietta Treska, Clementine Karageorgiou, Stefania Sotirli, Christos Giannoulis, Dimitra Papadimitriou, Ioannis Mylonas, Evaggelos Kouremenos, George S. Vlachos, Dimitrios Georgiopoulos, Despoina Mad...

2015
Nexhat Shatri Nazim Dakaj Afrim Blyta Kamber Zeqiraj Enver Isaku

Introduction: The purpose of the study is to investigate correlation between the expanded disability status scale, depression, quality of life (QoL) and age as well as to investigate the impact of the interferon beta-1b in the QoL of MS patients and its possible depressogenic effect. Material and methods: This prospective study included 70 randomly selected patients with MS treated in the clini...

Journal: :Acta clinica Croatica 2009
Aleksandar Jesić Dragana Stefanović Nenad Delibasić Marija Semnic Lorand Sakallasz Dragica Dobrenov Zeljko Zivanović Tamara Rabi-Zikić Milorad Zikić

The aim of this prospective study was to evaluate therapeutic effects in a cohort of 32 patients with relapsing-remitting multiple sclerosis (RRMS) that were continuously treated with interferon beta-1b during a three-year period and to compare the results obtained with literature data available. Additionally, dropouts and side effects were assessed. The annual relapse rate at three years of tr...

Journal: :Current medical research and opinion 2012
N S Roskell E A Zimovetz C E Rycroft B J Eckert D A Tyas

OBJECTIVES Previous systematic reviews and meta-analyses of treatments in relapsing-remitting multiple sclerosis (RRMS) derived their findings from either placebo-controlled studies only or separately from head-to-head and comparative studies. The purpose of this study is to compare annualized relapse rates (ARR) of fingolimod versus all of the commonly used first-line treatments in RRMS using ...

Journal: :Journal of Neurology, Neurosurgery & Psychiatry 2014

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