In this paper we present a simple but useful profiling tool for OpenMP applications similar in spirit to the MPI profiler mpiP [15]. We describe the implementation of our tool and demonstrate its functionality on a number of test applications.

BACKGROUND Recent studies have suggested that inflammation may play an important role in aging and the development of disabilities, but knowledge about its importance in the development of muscle weakness and functional disabilities in very old people is limited. This study examined associations between inflammatory markers and physical performance among nonagenarians. METHODS The population-...

The first line treatments for acute gouty arthritis are nonsteroidal anti-inflammatory drugs (NSAID), corticosteroids, and colchicine. However, these agents ineffective or contraindicated in a proportion of patients. Interleukin (IL)-1 is key mediator the pathogenesis arthritis. Recently, three IL-1-targeted have been developed, including anakinra, IL-1 receptor antagonist. authors present two ...

The cytokine channel’s mechanism for self-regulation involves the application of antagonistic cytokines that are synthesized to connect receptors and release soluble receptors. very first receptor antagonist was naturally present interleukin-1 (IL-1Ra). IL-1Ra protein forms disinfected from supernatants cultured monocytes on stacked IgG. family IL-1 consists IL-1α, IL-1β IL-1Ra. Human regulate ...

Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case challenging requires multidisciplinary approach. We report of occurring in pregnant patient who did not respond standard with glucocorticoids developed skin reaction IL-1 re...