A recent paper has identified the tumor suppressor APC as a linker protein between intermediate filaments and microtubules. In the absence of APC, intermediate filaments collapse and the cells are no longer polarized and fail to migrate.

Vimentin intermediate filaments move bi-directionally along microtubules in the cell. Recent work has identified the microtubule motor cytoplasmic dynein as the missing inward-directed motor that drives this movement.

background: breast cancer (bc) is the second most commonly diagnosed cancer after lung cancer. survival of bc patients is affected by intermediate events. this study was aimed to investigate the disease course of primary non-metastatic bc patients with first recurrence of the tumor (frt) as the intermediate event using the illness- death model. methods: this retrospective cohort study was condu...

belief in the lofty positions and excellences of the shi’īte imams (a.s.) and having faith in their miraculous acts and dominion over the world affairs underlies the authentic doctrine of unconditional guardianship (wilāya al-takwīnī). when the imams’ devotees try to maintain a demigod status for the imams in line with this – possibly loving and devotional – belief beyond the conventional limit...