In the face of contradictory information, people must rely on their instincts as much as the facts to size up potential threats.

The manuscript advances a hypothesis that there are few fundamental principles of neural organization of cognition, which explain several wide areas of the cognitive functioning. We summarize the fundamental principles, experimental, theoretical, and modeling evidence for these principles, relate them to hypothetical neural mechanisms, and made a number of predictions. We consider cognitive fun...

What mechanisms control circadian rhythms in the gastrointestinal tract and how does this impact nutrient metabolism? The deadenylase and leucine zipper protein Nocturnin is now shown to play a central role.

First-pass metabolism is a common cause of incomplete and variable absolute bioavailability for an orally dosed drug. The drug-metabolizing enzyme CYP3A4 is often implicated in this process, resulting, in some cases, in systemic exposures of less than 15% of the administered dose. By creating an elegant CYP3A4-transgenic mouse model, van Herwaarden et al. show in this issue of the JCI that firs...