In the development process of drugs for different diseases the pharmaceutical companies spend a lot of resources in the preclinical phase when researching for compounds as drug candidates. In the matter of osteoarthritis (degenerative joint disease), part of the research includes test on mice which spontaneously develop the disease. It is difficult to determine the level of osteoarthritis (OA) ...

Abstract The present study aimed to assess the influence of dietary chitosan on production performance, nutrient digestibility, slaughter traits, immune function, cecal microbiota, and intestinal histomorphometry growing rabbits for 56 days. In total, sixty New Zealand White male aged 35 days (574±7.26 g, mean ± SEM) were arbitrarily assigned four groups. experimental diets fortified with powde...

brachiocephalic arteries in quails are large arteries which are arising separately from the aortic arch. the aim of the present study was to determine the histomorphometric aspects of brachiocephalic arteries in the japanese quail. the different layers of the brachiocephalic artery were studied quantitatively in 10, 20 and 60 days-old japanese quail; (n = 6) and both sexes. luminal diameter, th...

We assessed the use of a filler compound together with the osteoinductive demineralized bone matrix (DBM), Colloss E. The filler was comprised of carboxymethyl-cellulose and collagen type 1. The purpose of the study was to see if the filler compound would enhance the bone formation and distribute the osteoinductive stimulus throughout the bone defect. Six sheep underwent a bilateral humerus dri...

A bone biopsy with prior tetracycline labeling is the gold standard to diagnose renal osteodystrophy. In cases of missing labels, it still paramount gain clinically relevant information from extracted sample, by evaluating static histomorphometry. This study investigates diagnostic performance histomorphometry for evaluation high and low turnover. Transiliac biopsies taken pre- or post- kidney ...