BACKGROUND Intraarticular injections for the local treatment of osteoarthritis are widely used in the office or hospital setting. Septic arthritis is a potential catastrophic complication of intraarticular injection, as bacterial arthritis of any cause is associated with up to 15% mortality and residual impairment of joint function in up to 50% of survivors. There is lack of evidence regarding ...

BACKGROUND Although in clinical use, there is only 1 published case report on the efficacy of intraarticular regeneration injection therapy (RIT) (a.k.a. prolotheraphy). This report supports a rationale for future clinical trials of this technique. OBJECTIVE To assess the efficacy of intraarticular zygapophysial joint RIT in patients with chronic whiplash related neck pain that failed other c...

PVNS is a rare disorder characterised by benign proliferation of synovial tissue. The treatment is surgical but relapse rate is high (8% to 46%). We report a 13 years old girl with PVNS of the left knee diagnosed in February 2003. Three months after diagnosis she underwent surgical synovectomy. Two years later important swelling of left knee with pain and limitation of movement developed and MR...

Background: Knee osteoarthritis (KOA) causes joint pain and dysfunction that severely affects the patient’s ability to walk. Arthroscopy combined with intraarticular injection of sodium hyaluronate can slow development knee osteoarthritis, but there is a lack rigorous evidence-based medicine evaluation, it has not been recognized by some scholars at home abroad. This paper analyzed clinical eff...

The objective of the study was to determine whether strenuous running exercise produces a significant amount of fibrosis in the infrapatellar fat pad (IFP) of the knee and whether intraarticular injections of hyaluronan (HA) protect fibrosis in the IFP in a rat running model. Strenuous running exercise was performed on a rodent treadmill with 5% inclination using Wistar rats. After the exercise...

We previously reported increased release of the excitatory amino acid (EAA) neurotransmitters, glutamate and aspartate, during the early stage of experimental osteoarthritis (OA). Our present objective was to study the effect of intraarticular injection of hyaluronic acid (HA) on OA development, and to analyze concomitant changes in EAA levels in dialysates of anterior cruciate ligament-transec...

OBJECTIVE To study the correlation between histological findings and Magnetic Resonance Imaging (MRI) findings in experimentally induced arthritis in the temporomandibular joint (TMJ) of growing rabbits and to study the effect of intraarticular corticosteroid injections. METHODS Arthritis was induced by ovalbumin in the left TMJ of 44 pre-sensibilized rabbits. Nine animals died during this pr...

A 63 year old man with bilateral knee osteoarthritis underwent an intraarticular steroid injection. After two days the patient developed severe pain and marked effusion in the left knee joint. Cultures were negative. He subsequently underwent bilateral knee replacement. The synovial biopsy of the left knee revealed marked granulation tissue and peculiar neutrophilic response against degenerated...