Sixty-one percent of intravenous drug users (IVDUs) who received outpatient parenteral antibiotic therapy (OPAT) failed treatment. Hospital readmission and adverse drug reactions occurred in 25%. By multivariate analysis, time since last IVDU was associated with failure (P = .04). Intravenous drug users requiring OPAT are at high risk for failure; additional studies are needed to explore altern...

OBJECTIVE To study the clinical symptoms associated with seroconversion for HIV-1 among misusers of intravenous drugs. DESIGN Case-control study in cohorts of drug misusers and homosexual men. SETTING Outpatient clinic, Municipal Health Service, Amsterdam. SUBJECTS Misusers of intravenous drugs from our prospective cohort who seroconverted for HIV. Controls were drug users positive for HI...

OBJECTIVE to assess whether male prostitution is an independent risk factor for HIV infection among male (intravenous and nonintravenous) drug users. DESIGN a cross-sectional study. SETTING various low-threshold methadone clinics and the sexually transmitted diseases clinic of the Municipal Health Service in Amsterdam and a drug-treatment centre in The Hague. PARTICIPANTS 343 male intrave...