This study reports the results of an open trial of Sodium Valproate in tardive-dyskinesia. Fifteen patients identified having tardive dyskinesia by two psychiatrists independently were treated with Sodium Valproate in dosage of 1200 mg/day for 4 weeks. Assessments were made on abbreviated Dyskinesia Scale. There was statistically significant improvement after 2 and 4 weeks of treatment. Authors...

background: omega-3 polyunsaturated fatty acids (pufa) have beneficial effects on both specific and non-specific inflammatory reactions. the aim of this study was to evaluate the effect of dietary supplementation with fish oil in migraine prevention. methods: a 12-week, randomized, single-blind clinical trial was conducted from october 2008 to june 2009. a total of 67 patients (52 women, 15 men...

Introduction: Epilepsy is a clinical syndrome in which seizures have a tendency to recur. Sodium valproate is the most effective drug in the treatment of all types of generalized seizures. Finding the optimal dosage (the lowest effective dose) of sodium valproate is a real challenge to all neurologists. In this study, a new approach based on Adaptive Neuro-Fuzzy Inference System (ANFIS) was pre...

Objectives: The objective was to evaluate the seizure provoking effect of sumatriptan, and its abolition with fluoxetine in the pentylenetetrazolinduced seizures in rats. Methods: 100 Sprague-Dawley rats of either sex were randomized into 10 groups with each group consisting 10 rats. The first group was taken as a control group which received distilled water. The second group and the third grou...

conclusions it became clear at the end of the study that the effectiveness of two drugs were the same and they didn’t have any meaningful difference. according to the result gained from this study, levetiracetam is a proper alternative treatment instead of sodium valproate which has appropriate effectiveness along with lower complications. results comparison of mean generalized tonic colonic at...

New onset refractory status epilepticus (NORSE) is a neurological emergency and difficult to treat condition. We report a case of involuntary movements resulting from thiopentone sodium infusion during the management of refractory status epilepticus. A young woman was admitted with fever and NORSE in the neurology intensive care unit. In addition to supportive measures, she was treated with int...

Background: Gamma-amino butyric acid (GABA) agonists have been effective in the treatment of withdrawal from benzodiazepines, sedatives and alcohol, and reducing the craving for cocaine. Valproate is a GABAergic drug effective in the treatment of neuropathic pain and also in withdrawal from benzodiaepines, sedatives, and alcohol. The purpose of this double-blind trial was to evaluate the ef...