BACKGROUND p63 is a homologue of the p53 tumor suppressor gene and its protein is selectively expressed in the basal cells of a variety of epithelial tissues. It has recently been confirmed that p63 is expressed in the basal cells of normal prostate glands but not in prostatic carcinomas. Whether expression of p63 in breast correlates with tumor progression is the focus of this study. METHODS...

Distinguishing between reactive mesothelial proliferations and adenocarcinoma is often very difficult. Ancillary studies, in particular immunohistochemistry, are often critical in detecting malignant epithelial cells, especially in serous effusion specimens. MOC-31 and Ber-EP4 are antibodies which target the epithelial cell adhesion molecule (Ep-CAM, TACSTD1) expressed in epithelial cells, and ...

OBJECTIVE The aim of this study was to examine the expression of matriptase and survivin in breast carcinoma and correlate with clinicopathological parameters. METHODS Immunohistochemical analysis of matriptase and survivin were performed in tissue microarray slides of 290 cases, including 11 normal breast tissue; 27 fibrocystic disease; 17 fibroadenoma; 6 atypical ductal hyperplasia; 39 duct...

Invasive ductal carcinoma NOS, or no special type, is the most common type of breast cancer representing 65% to 75% of mammary carcinomas (1,2). Depending on the size of the lesion, size of the breast, and proximity of the lesion to the skin, patients can present with a hard, fixed, palpable mass that may cause skin thickening and retraction (Fig. 8.1). If the cancer is in the subareolar area, ...

mucinous carcinoma of the breast is a well differentiated, rare histological type of invasive ductal carcinoma, seen in oldest median age (69 years). we describe a case of a 60 yr old female with large right breast mass of 10 years duration with no nodal involvement. the reasons to present this case are 1) because of its rarity. 2) despite having a large tumour size, the axillary lymph node is ...

OBJECTIVES Biological markers that predict the development of invasive breast cancer are needed to improve personalized therapy for patients diagnosed with ductal carcinoma in situ. We investigated the role of basal cytokeratin 5/6 in the risk of invasion in breast ductal carcinoma in situ. METHODS We constructed tissue microarrays using 236 ductal carcinoma in situ samples: 90 pure samples (...

OBJECTIVE To evaluate the expression of PD-L1 (programmed death 1 ligand 1, PD-L1) and its clinical significance in breast invasive ductal carcinoma. METHODS Tumor samples were collected from 64 cases of breast invasive ductal carcinoma patients, and tumor adjacent normal breast tissue were obtained as normal control. The expression of PD-L1 were examined by immunohistochemical staining and r...

introduction: breast cancer is the most common cause of cancer-related death among women. the aim of this study was to assess the pathologic findings of patients with breast cancer who were referred to the pathology ward in bandarabbas during 2002 to 2010. methods and materials: in this descriptive study in 2010, all patients with breast cancer who were referred to the pathology ward of bandara...

OBJECTIVE To evaluate the expression of the cell adhesion molecules E-cadherin and N-cadherin and the transcription factor Snail in invasive ductal breast carcinomas and to determine their relationships with clinicopathological features. METHODS Immunohistochemistry was used to examine E-cadherin, N-cadherin, and Snail protein expression in 132 invasive breast carcinomas. RESULTS The expres...