The role of cytokine- and T helper (Th)-dependent lung mucosal antifungal immunity in murine invasive pulmonary aspergillosis (IPA) was investigated. Intact or leukopenic DBA/2 mice were resistant or highly susceptible, respectively, to infection caused by multiple intranasal injections of viable Aspergillus fumigatus conidia. Resistance was associated with unimpaired innate antifungal activity...

Invasive pulmonary aspergillosis (IPA) is a fulminant and highly lethal infection of severely immunocompromised patients with a reported mortality rate of approximately 60%.1 Patients who are at considerable risk include those who are granulocytopenic due to bone marrow transplantation, those who are undergoing intensive cytotoxic chemotherapy for the treatment of neoplasia, and those with a hi...

A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. S...

OBJECTIVE To evaluate vessel involvement and the role of multidetector computed tomography (MDCT) in the earlydiagnosis of invasive pulmonary aspergillosis (IPA) in patients with febrile neutropenia and antibiotic-resistant feverundergoing autologous bone morrow transplantation. MATERIAL AND METHODS In all, 74 pulmonary MDCT examinations in 37 consecutive hematopoietic stem celltransplantatio...

Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection that predominantly affects severely immunocompromised patients, particularly those with prolonged neutropenia or organ transplantation.1 Definitions have been developed that facilitate the diagnosis of IPA in immunocompromised patients with cancer or hematologic malignancy.2 Subsequent publications explored IPA in non...

BACKGROUND The clinical impact of the galactomannan (GM) test for the diagnosis of invasive pulmonary aspergillosis (IPA) is controversial. Our study evaluated the incidence and trends of IPA and GM testing in patients with aspergillus infections. METHODS We conducted a nationwide inpatient population study using the Taiwan National Health Insurance Research Database. A total of 346 IPA (62.1...

immune deficiency. However, two aspects of this report require further discussion. First, instead of invasive pulmonary aspergillosis (IPA), we believe the precise diagnosis should be chronic necrotizing pulmonary aspergillosis (CNPA). To start with, the patient does not show any clinical symptoms of IPA, nor are her COPD symptoms getting any more severe. The occurrence of IPA in COPD patients ...

Invasive pulmonary aspergillosis (IPA) is the most frequent form of invasive fungal diseases in immunocompromised patients. However, there are only a few studies on IPA in immunocompromised children in Korea. This study was designed to characterize IPA in Korean children with hematologic/oncologic diseases. Medical records of children with hematologic/oncologic diseases receiving antifungal the...

Invasive pulmonary aspergillosis (IPA) is an important cause of mortality in patients with hematologic malignancies. The reported incidence of IPA in the context of chronic obstructive pulmonary disease (COPD) seems to increase. Approximately 1%-2% of overall fatal cases of IPA occur in COPD patients. The combination of factors such as lung immune imbalance, long-term corticosteroid use, increa...

immune deficiency. However, two aspects of this report require further discussion. First, instead of invasive pulmonary aspergillosis (IPA), we believe the precise diagnosis should be chronic necrotizing pulmonary aspergillosis (CNPA). To start with, the patient does not show any clinical symptoms of IPA, nor are her COPD symptoms getting any more severe. The occurrence of IPA in COPD patients ...