shigella species (spp.) are gram-negative bacteria that are responsible for shigellosis. although it can be controlled via antibiotics, increasing number of antibiotic resistant isolates of shigella have been reported. therefore, other strategies such as production of specific vaccine against this organism could be a suitable therapeutic approach. attenuated live vaccines produced by gene delet...

December 22, 2016 Type Package Title Identification of mutational clusters in protein quaternary structures. Version 1.6.0 Date 2014-09-25 Author Gregory Ryslik, Yuwei Cheng, Hongyu Zhao Maintainer Gregory Ryslik Description Identifies clustering of somatic mutations in proteins over the entire quaternary structure. License GPL-2 biocViews Clustering, Proteomics, Somat...

February 1, 2017 Type Package Title Identification of mutational clusters in protein quaternary structures. Version 1.6.0 Date 2014-09-25 Author Gregory Ryslik, Yuwei Cheng, Hongyu Zhao Maintainer Gregory Ryslik Description Identifies clustering of somatic mutations in proteins over the entire quaternary structure. License GPL-2 biocViews Clustering, Proteomics, Somati...

There are major gaps in the measurement of adoption and stringency countries’ climate actions policies, notably a manner coherent across countries, time, sectors instrument types. The policies framework (CAPMF) aims to fill this gap. It is structured harmonised mitigation policy database that informs about action. CAPMF was developed under International Programme for Action on Climate (IPAC). c...

The native Invaplex (InvaplexNAT) vaccine and adjuvant is an ion exchange-purified product derived from the water extract of virulent Shigella species. The key component of InvaplexNAT is a high-molecular-mass complex (HMMC) consisting of the Shigella lipopolysaccharide (LPS) and the invasin proteins IpaB and IpaC. To improve product purity and immunogenicity, artificial Invaplex (InvaplexAR) w...

November 21, 2016 Type Package Title Identification of mutational clusters in protein quaternary structures. Version 1.6.0 Date 2014-09-25 Author Gregory Ryslik, Yuwei Cheng, Hongyu Zhao Maintainer Gregory Ryslik Description Identifies clustering of somatic mutations in proteins over the entire quaternary structure. License GPL-2 biocViews Clustering, Proteomics, Somat...

Pull-down assays can identify members of protein complexes but suffer from co-isolation of contaminants. The problem is particularly acute when the specifically interacting partners are of low-abundance and/or bind transiently with low affinity. To differentiate true interacting partners from contaminants, we have combined SILAC labelling with a proteomic method called "Interactomes by Parallel...

Shigella is a genus of highly adapted bacterial pathogens that cause bacillary dysentery in humans. Bacteria reaching the colon invade intestinal epithelial cells by a process of bacterial-directed endocytosis mediated by the Ipa proteins: IpaB, IpaC, and IpaD of Shigella. The invasion of epithelial cells is thought to be a receptor-mediated phenomenon, although the cellular components of the h...

Shigella flexneri, the causative agent of shigellosis, is a gram-negative bacterial pathogen that initiates infection by invading cells within the colonic epithelium. Contact with host cell surfaces induces a rapid burst of protein secretion via the Shigella type III secretion system (TTSS). The first proteins secreted are IpaD, IpaB, and IpaC, with IpaB and IpaC being inserted into the host ce...

The second author was invited to write this paper by the Intellectual Property Advisory Committee (IPAC) of the UK Patent Office. She is grateful to the Director of the Intellectual Property Institute, Paul Leonard, who provided a small grant to employ Padraig Dixon, who drafted much of the eventual text. We also acknowledge the assistance of Dr. Mark Rogers, Harris Manchester College, in respe...