Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer. Snake venom toxins contributed significantly to the treatment of many medical conditions. There are many published studies describing and elucidating the anti-cancer potential of snake venom. Cancer therapy is one of the main areas for the use of prote...

Snakebites can present local or systemic envenomation, while neurotoxicity and respiratory paralysis are the main cause of death. The mainstay of management is anti-snake venom (ASV), which is highly effective, but liable to cause severe adverse reactions including anaphylaxis. The types of adverse reaction to polyvalent anti-snake venom have not been previously studied in Bangladesh. In this p...

Snake venom has been hypothesized to have originated and diversified through a process that involves duplication of genes encoding body proteins with subsequent recruitment of the copy to the venom gland, where natural selection acts to develop or increase toxicity. However, gene duplication is known to be a rare event in vertebrate genomes, and the recruitment of duplicated genes to a novel ex...

  Objective(s): Snake venoms contain complex mixture of proteins with biological activities. Some of these proteins affect blood coagulation and platelet function in different ways. Snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. In the present study, purification of anticoagulation facto...

Snake venom, as a natural biotoxin, is widely present in nature and can act coordination with variety of signal regulatory proteins, playing significant role the regulation tumor cell proliferation, metastasis, invasion, angiogenesis. Malignant tumors have long attracted attention medical community leading cause death humans. In this paper, we focus on reviewing progress snake venom apoptosis, ...

The complete sequence characterization of snake venom proteins by mass spectrometry is rather challenging due to the presence of multiple isoforms from different protein families. In the present study, we investigated the tryptic digest of the venom of the viperid snake Sistrurus catenatus edwardsii by a combined approach of liquid chromatography coupled to either electrospray (online) or MALDI...

BACKGROUND The variation of venom composition with geography is an important aspect of intraspecific variability in the Vipera genus, although causes of this variability remain unclear. The diversity of snake venom is important both for our understanding of venomous snake evolution and for the preparation of relevant antivenoms to treat envenomations. A geographic intraspecific variation in sna...

What is the composition of snake venom?  Snake venom is a cocktail of several different proteins and enzymes  Protein constitute 90% of dry weight of venoms o Proteins include Lethal Polypeptides and Hydrolytic enzymes (Proteases, Nucleases, Peptidases, Lipases, etc) that can either enhance and/or contribute to the toxic effect of the venom o Enzymes cause both local and systemic destruction ...

objective(s): snake venoms contain complex mixture of proteins with biological activities. some of these proteins affect blood coagulation and platelet function in different ways. snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. in the present study, purification of anticoagulation factor from veno...

Snake bite is an important and serious global health issue. Till date anti snake venom serum is the only therapeutic remedy available for treating the snake bite victims. Infusion of ASV may lead to adverse reactions ranging from pruritus, urticaria to potentially fatal anaphylaxis. The development of ASV is also a costly and time consuming process requiring ideal storage conditions. Though Ant...