We describe a new approach for making real-time measurements of exocytosis and endocytosis in neurons and neuroendocrine cells. The method utilizes interference reflection microscopy (IRM) to image surface membrane in close contact with a glass coverslip (the "footprint"). At the synaptic terminal of retinal bipolar cells, the footprint expands during exocytosis and retracts during endocytosis,...

The Canadian Food Inspection Agency (CFIA) regulates environmental releases of plants with novel traits, which include transgenic plants such as Bt crops. Bt crops are regulated in Canada because they express insect resistance novel to their species. Commercialization of crops with novel traits such as the production of insecticidal Bt proteins requires an approval for environmental release, as...

Nowadays there are more than thirty maturity models in different knowledge areas. Maturity model is an area of interest that contributes organizations to find out where they are in a specific knowledge area and how to improve it. As Information Resource Management (IRM) is the concept that information is a major corporate resource and must be managed using the same basic principles used to mana...

the aim of this study was to evaluate the marginal adaptation of biodentine in comparison with mineral trioxide aggregate (mta) and intermediate restorative material (irm), as a root end filling material, using scanning electron microscopy (sem).thirty permanent maxillary central incisors were chemo-mechanically prepared and obturated. three millimetres of the root end were resected and 3mm ret...

Invariant risk minimization (IRM) has recently emerged as a promising alternative for domain generalization. Nevertheless, the loss function is difficult to optimize nonlinear classifiers and original optimization objective could fail when pseudo-invariant features geometric skews exist. Inspired by IRM, in this paper we propose novel formulation generalization, dubbed invariant information bot...

Wedevelop aBayesian binary ItemResponseModel (IRM),whichwedenote as Test Anxiety Model (TAM), for estimating the proficiency scores when individuals might experience test anxiety. We consider order restricted item parameters conditionally to the examinees’ reported emotional state at the testing session.We consider three test anxiety levels: calm, anxious and very anxious. Using simulated data ...

Synthetic immune response modifiers (IRM) such as imidazoquinolines can selectively activate human TLR7 or TLR8. Although these endosomal TLRs are close relatives, TLR7-deficient mice are unresponsive to TLR8 agonist IRMs. Similarly, natural ssRNA cannot activate murine TLR8, leading to the belief that murine TLR8 is nonfunctional. In this study, we transfected HEK293 cells with murine TLR8 and...

Nowadays there are more than thirty maturity models in different knowledge areas. Maturity model is an area of interest that contributes organizations to find out where they are in a specific knowledge area and how to improve it. As Information Resource Management (IRM) is the concept that information is a major corporate resource and must be managed using the same basic principles used to mana...

Bone tissue reactions to EBA, IRM, and cyanoacrylate cement (Base Liner) were studied in the rat mandible using an intraosseous implant method. Osseous cavities (1.4 mm in diameter) were surgically created in the mandibles, and materials were implanted in 60 male Wistar rats. Each specimen was evaluated histologically after 4 and 8 weeks. The development of fibrous connective tissue in direct a...