The chelating agent diethylenetriamine penta-acetic acid was used to measure iron stores in 83 patients with chronic liver disease. Iron chelation was normal in patients with chronic cholestasis. Chelation was increased above the control range in 14 out of 26 patients with alcoholic cirrhosis, in nine out of 28 patients with non-alcoholiccirrhosis, and in 11 out of 15 cirrhotics with a portacav...

The chelating agent diethylenetriamine penta-acetic acid was used to measure iron stores in 83 patients with chronic liver disease. Iron chelation was normal in patients with chronic cholestasis. Chelation was increased above the control range in 14 out of 26 patients with alcoholic cirrhosis, in nine out of 28 patients with non-alcoholic cirrhosis, and in 11 out of 15 cirrhotics with a portaca...

Neutrophil extracellular trap (NET) formation is a significant innate immune defense mechanism against microbial infection that complements other neutrophil functions including phagocytosis and degranulation of antimicrobial peptides. NETs are decondensed chromatin structures in which antimicrobial components (histones, antimicrobial peptides and proteases) are deployed and mediate immobilizati...

As a unique electron donor and acceptor, iron is an essential element in most biological systems. However, its chemical reactivity can result in iron potentially becoming a toxin when present in excessive quantities; accordingly, total body iron must be tightly regulated. As humans have no physiological mechanism for the elimination of excess iron, body iron is controlled mainly by the degree o...

The antioxidant and restoration potentials of hepatic injury by Prunus nepalensis Ser. (Steud), a wild fruit plant from the Northeastern region of India, were investigated. The fruit extract (PNME) exhibited excellent antioxidant and reducing properties and also scavenged the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical (IC50 = 30.92 ± 0.40 μg/ml). PNME demonstrated promising scavenging potency...

BACKGROUND Available iron chelation regimes in thalassaemia may achieve different changes in cardiac and hepatic iron as assessed by MR. The aim of this study was to assess the efficacy of four available iron chelator regimes in 232 thalassaemia major patients by assessing the rate of change in repeated measurements of cardiac and hepatic MR. RESULTS For the heart, deferiprone and the combina...

Transfusional iron overload in patients with chronic anemias can result in multiple organ failure. Experience in the management of iron overload in patients with myelodysplastic syndromes is limited, as many do not receive chelation therapy due to short-life expectancy and the difficulties associated with the administration of the current reference standard chelator, deferoxamine. There have, h...

Introduction: Eastern India -the melting pot of different heterozygous Sickle cell syndrome. Mostly NTDT, we wanted to study the pattern of iron overload in this heterogeneous yet homogenous group of patients. As there is no such study from this part of the world, it would reveal the true state of iron overload, appropriate test/s and chelation requirement. Methodology: 152 subjects of Sickle c...

Background Iron chelation treatment has increased life expectancy of patients with beta thalassemia major. Accurate assessement of heart iron overload is essential for managing chelation therapy. Nowadays, MRI-based iron overload quantification became the gold standard technique. However it remains too expensive in countries that cannot afford such technology, which ironically are endemic count...

conclusion adrenal iron in β-tm can be reliably measured in 3 tesla mri. the results highlight the absence of correlation between adrenal iron deposition both with serum ferritin and hepatic iron. results among patients, there was no significant correlation between plasma ferritin and adrenal t2*. significant difference was detected among t2* values of adrenals between the patient and control g...