Vecuronium is hydrolyzed in the body to 3-deacetyl (ORG 7268), 17-deacetyl (ORG NC58), and 3, 17-bis-deacetyl (ORG 7402) derivatives. Interactions of vecuronium and these metabolites were studied in phrenic nerve-hemidiaphragm preparations of rats. As already reported, ORG 7268 had a potent neuromuscular blocking action, and ORG NC58 and ORG 7402 had a weak neuromuscular blocking action. As exp...

Org NC 45 60-80 microgram kg-1 was administered to 20 pregnant women undergoing general anaesthesia for Caesarean section. Org NC 45 plasma concentrations were measured fluorimetrically in samples of maternal, venous and arterial cord blood obtained at delivery. The venous cord to maternal concentration ratio averaged 11% and was not influenced by the interval between induction and delivery. Th...

Aims: The COVID-19 pandemic disrupted healthcare globally and several authors have observed a change in the presentation of acute appendicitis within period. We an upsurge complicated first 4 weeks 2021. aim to compare our findings with similar period prior pandemic.
 Study design: Observational cohort study.
 Place duration study: Benue State University Teaching Hospital(BSUTH), Maku...

A robot exploring beneath the vulnerable Antarctic glacier has found new features that affect its melt rate.