EVEN BEFORE the endothelium-derived relaxing factor (EDRF) was known to be nitric oxide (NO), it was recognized that it could be inactivated by the radical superoxide (O2 · ) (16). Once the EDRF was identified as NO, the chemistry underlying this phenomenon was obvious. Both NO and O2 · are radicals, and rapidly react with one another to form the strong oxidant peroxynitrite, which ultimately d...

Remote postconditioning (RPost) has a great therapeutic potential for protecting the myocardium during ischemiareperfusion in clinical practice. At same time, an important problem limiting use of conditioning effects clinic is presence metabolic disorders patient. The aim this work was to assess effect induced syndrome (iMetS) on efficacy infarct-limiting remote ischemic rats and study mechanis...

Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction proteins, development muscle contracture etc. It was shown that hydrogen sulfide (H2S) and precursor its synthesis amino acid L-cysteine provided cardioprotective effect against ischemiarepe...

and it is an important factor that leading to cardiac ischemiareperfusion injury. In the past, most attention was focused on cardiac cells. While in recent years, myocardiac microvascular endothelial cells (MMECs) attracted scholar’s attention. The one hand, endothelial cells participate in many important body balance regulation, and can synthesize and secrete a variety of biologically active s...

Early reperfusion of the ischemic myocardium has been shown to reduce mortality in acute myocardial infarction. Unfortunately, reperfusion, although necessary to relieve ischemia, may be followed by morphological, functional, and electrical changes that result in additional myocardial damage, known as reperfusion injury. In animal models, several pharmacologic agents and reperfusion strategies ...

Minekawa, Ryoko, Takashi Takeda, Masahiro Sakata, Masami Hayashi, Aki Isobe, Toshiya Yamamoto, Keiichi Tasaka, and Yuji Murata. Human breast milk suppresses the transcriptional regulation of IL-1 -induced NFB signaling in human intestinal cells. Am J Physiol Cell Physiol 287: C1404–C1411, 2004. First published June 30, 2004; doi:10.1152/ajpcell.00471.2003.—Neonatal necrotizing enterocolitis (NE...

Takahashi, Yoshihito, Raymond W. Ganster, Andrea Gambotto, Lifang Shao, Takashi Kaizu, Tong Wu, Gautam P. Yagnik, Atsunori Nakao, George Tsoulfas, Takashi Ishikawa, Toyokazu Okuda, David A. Geller, and Noriko Murase. Role of NFB on liver cold ischemiareperfusion injury. Am J Physiol Gastrointest Liver Physiol 283: G1175–G1184, 2002. First published July 17, 2002; 10.1152/ajpgi.00515.2001.—The r...