In recent years there has been great progress in applying FET-type biosensors for highly sensitive biological detection. Among them, the ISFET (ion-sensitive field-effect transistor) is one of the most intriguing approaches in electrical biosensing technology. Here, we review some of the main advances in this field over the past few years, explore its application prospects, and discuss the main...

This paper presents a comprehensive review of the ion-sensitive field-effect transistor (ISFET) and its applications in biomolecular sensing and characterization of electrochemical interfaces. An introduction to the physics of field-effect transistors is presented, followed by a study of the properties of electrolytic solutions and electrolyte interface surface effects. Full modeling of the ion...

© 2009 Apinunt Thanachayanont et al. 243 ABSTRACT⎯A novel ultra-low-power readout circuit for a pH-sensitive ion-sensitive field-effect transistor (ISFET) is proposed. It uses an ISFET/reference FET (REFET) differential pair operating in weak-inversion and a simple current-mode metal-oxide semiconductor FET (MOSFET) translinear circuit. Simulation results verify that the circuit operates with e...

Enzyme sensors based on the measurement of pH consist basically of a pH-sensitive electrode to which an enzyme-loaded membrane is attached. The conversion of substrate in the immobilized enzyme membrane results in a local change in pH which can then be measured. The pH-sensitive electrode used is usually a glass membrane electrode or an ISFET. In 1980, Caras and Janata [l] described the first I...

Adenosine triphosphate (ATP) not only functions as an energy-carrier substance and an informative molecule, but also acts as a marker substance in studies of both bio-traces and cellular/tissular viability. Due to the importance of the ATP function for living organisms, in situ assays of ATP are in demand in various fields, e.g., hygiene. In the present study, we developed an ATP sensor that co...

It is crucial to have early detection of prostate cancer as it the third most common in men and Prostate Specific Antigen (PSA) a protein-based biomarker commonly used achieve purpose. Besides, ISFET integrated with nanostructures such nanowire nanosphere has been focus research for disease diagnosis. Simulations are carried out Biosensor Lab investigate performance planar, structures detecting...

Sensors play the most important role in observing changes in an environment they are a part. They detect even the smallest changes and send the information to other electronic devices. Making sure that these sensors provide an accurate output is equally crucial, as the data it measures and collects are used for analysis. Until now, calibrating sensors has been done manually by following a seque...