In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

transforming growth factor betas (tgf?s) are one of the most widespread and versatile cytokines. the three mammalian tgf? isoforms, ?1, ?2, and ?3, and their receptors regulate proliferation of neuronal precursors as well as survival and differentiation in neurons of developing and adult nervous system. functions of tgf?s has a wide spectrum ranging from regulating cell proliferation and differ...

Haplolethals (HL) are regions of diploid genomes that in one dose fatal for the organism. Their biological meaning is obscure because heterozygous loss-of-function mutations result dominant lethality (DL) and, consequently, should be under strong negative selection. We report an depth study HL associated to gene wings up A ( wupA ). It encodes 13 transcripts (A-M) yield 11 protein isoforms (A-K...

Peroxisome proliferator-activated receptors (PPARs), which exert multiple key signaling functions in human skin physiology and pathology, exist various isoforms. These include canonical (cPPARγ1-4) dominant negative isoforms (dnPPARγ: γORF4 (γ1-3ORF4), truncated PPARG (PPARγtr) PPARγΔ5. Yet their exact expression patterns remain unclear. Therefore, we have localized quantified PPARγ biopsies fr...

Adverse health outcomes caused by ambient particulate matter (PM) pollution occur in a progressive process, with neutrophils eliciting inflammation or pathogenesis. We investigated the toxico-transcriptomic mechanisms of PM real-life settings comparing healthy residents living Beijing and Chengde, opposing ends well-recognised air (AP) corridor China. recruits (BRs) uniquely expressed ~12,000 a...

Abstract Glioblastoma multiforme (GBM) is a lethal primary brain cancer with median survival of 14.6 months despite standard treatment maximal surgical resection, radiotherapy, and temozolomide (TMZ). Recent research has identified PIK3CB/p110β as the most important regulator AKT activation GBM cell survival. Utilizing pharmacogenomic databases Genomics Drug Sensitivity in Cancer (GDSC) Cell Li...

Pharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic potential to restore memory function in Alzheimer’s disease (AD), but will likely evoke adverse side effects. As PDE4D encodes multiple isoforms, targeting specific isoforms may improve treatment efficacy and safety. Here, we investigated whether isoform expression DNA methylation is affected AD changes are associated wit...